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dc.creatorHernández Muñoz, Inmaculadaes
dc.creatorFiguerola, Elisabethes
dc.creatorSánchez Molina, Saraes
dc.creatorRodríguez, Evaes
dc.creatorFernández Mariño, María Isabeles
dc.creatorPardo Pastor, Carloses
dc.creatorÁlava Casado, Enrique dees
dc.creatorMora, Jaumees
dc.date.accessioned2020-05-18T10:37:59Z
dc.date.available2020-05-18T10:37:59Z
dc.date.issued2016-06-15
dc.identifier.citationHernández Muñoz, I., Figuerola, E., Sánchez Molina, S., Rodríguez, E., Fernández Mariño, M.I., Pardo Pastor, C.,...,Mora, J. (2016). RING1B contributes to Ewing sarcoma development by repressing the Na(V)1.6 sodium channel and the NF-kappa B pathway, independently of the fusion oncoprotein. Oncotarget, 7 (29), 1-18 p.
dc.identifier.issn1949-2553es
dc.identifier.urihttps://hdl.handle.net/11441/96828
dc.description.abstractEwing sarcoma (ES) is an aggressive tumor defined by EWSR1 gene fusions that behave as an oncogene. Here we demonstrate that RING1B is highly expressed in primary ES tumors, and its expression is independent of the fusion oncogene. RING1B-depleted ES cells display an expression profile enriched in genes functionally involved in hematological development but RING1B depletion does not induce cellular differentiation. In ES cells, RING1B directly binds the SCN8A sodium channel promoter and its depletion results in enhanced Nav1.6 expression and function. The signaling pathway most significantly modulated by RING1B is NF-κB. RING1B depletion results in enhanced p105/p50 expression, which sensitizes ES cells to apoptosis by FGFR/SHP2/STAT3 blockade. Reduced NaV1.6 function protects ES cells from apoptotic cell death by maintaining low NF-κB levels. Our findings identify RING1B as a trait of the cell-of-origin and provide a potential targetable vulnerability.es
dc.description.sponsorshipMinisterio de Economía y Competitividad SAF2012-31089 and SAF2015-69762-Res
dc.description.sponsorshipMEC FEDER RD12/0036/0017, PT13/0010/0056, RTC-2014- 2102-1, ISCIII Sara Borrell CD06/00001, PI12/03102, PI14/01466es
dc.description.sponsorshipEuropean FP7 Projects EuroSARC FP7- HEALTH-2011-two-stage, Project 278742 EUROSARCes
dc.description.sponsorshipEuroewing FP7-HEALTH.2013.2.4.1-1, Project 602856es
dc.formatapplication/pdfes
dc.format.extent18es
dc.language.isoenges
dc.publisherImpact Journalses
dc.relation.ispartofOncotarget, 7 (29), 1-18 p.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectRing 1Bes
dc.subjectEwing Sarcomaes
dc.subjectVoltage-gated sodium channeles
dc.subjectNF-kBes
dc.subjectFGFR/SHP2/STAT3es
dc.titleRING1B contributes to Ewing sarcoma development by repressing the Na(V)1.6 sodium channel and the NF-kappa B pathway, independently of the fusion oncoproteines
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Citología e Histología Normal y Patológicaes
dc.identifier.doi10.18632/oncotarget 10092es
dc.journaltitleOncotargetes
dc.publication.volumen7es
dc.publication.issue29es
dc.publication.initialPage1es
dc.publication.endPage18es

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