dc.creator | Hontecillas Prieto, Lourdes | es |
dc.creator | García-Domínguez, Daniel J. | es |
dc.creator | García Mejías, Rosa | es |
dc.creator | Ramírez Villar, Gema | es |
dc.creator | Sáez, Carmen | es |
dc.creator | Álava Casado, Enrique de | es |
dc.date.accessioned | 2020-05-13T09:54:57Z | |
dc.date.available | 2020-05-13T09:54:57Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Hontecillas Prieto, L., García Domínguez, D., García Mejías, R., Ramírez Villar, G., Sáez, C. y Álava, E.d. (2017). HMGA2 overexpression predicts relapse susceptibility of blastemal Wilms tumor patients. Oncotarget, 8 (70), 1-15 p. | |
dc.identifier.issn | 1949-2553 | es |
dc.identifier.uri | https://hdl.handle.net/11441/96541 | |
dc.description.abstract | Wilms tumor (WT) is an embryonal malignant neoplasm of the kidney that
accounts for 6–7% of all childhood cancers. WT seems to derive from multipotent
embryonic renal stem cells that have failed to differentiate properly. Since mechanisms
underlying WT tumorigenesis remain largely unknown, the aim of this study was
to explore the expression of embryonic stem cell (ESC) markers in samples of WT
patients after chemotherapy treatment SIOP protocol, as the gene expression
patterns of ESC are like those of most cancer cells. We found that expression of ESC
markers is heterogeneous, and depends on histological WT components. Interestingly,
among ESC markers, HMGA2 was expressed significantly stronger in the blastemal
component than in the stromal and the normal kidney. Moreover, two subsets of
patients of WT blastemal type were identified, depending on the expression levels of
HMGA2. High HMGA2 expression levels were significantly associated with a higher
proliferation rate (p=0.0345) and worse patient prognosis (p=0.0289). The expression
of HMGA2 was a stage-independent factor of clinical outcome in blastemal WT
patients. Our multivariate analyses demonstrated the association between LIN28B–
LET7A–HMGA2 expression, and the positive correlation between HMGA2 and SLUG
expression (p=0.0358) in blastemal WT components. In addition, patients with a
poor prognosis and high HMGA2 expression presented high levels of MDR3 (multidrug
resistance transporter). Our findings suggest that HMGA2 plays a prominent role in
the pathogenesis of a subset of blastemal WT, strongly associated with relapse and
resistance to chemotherapy. | es |
dc.description.sponsorship | Consejería de Salud, Junta de Andalucía (PI-0197-2016) | es |
dc.description.sponsorship | Junta de Andalucía PI-0197-2016 | es |
dc.description.sponsorship | Instituto de Salud Carlos III FIS PI13/02282 | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad CIBERONC, PI1700464, RD06/0020/0059, FMGE y la Unión Europea FP7-HEALTH- 2011-two-stage, Project ID 278742 EUROSARC | es |
dc.description.sponsorship | Red Temática de Investigación Cooperativa en Cáncer RD12/0036/0017 | es |
dc.format | application/pdf | es |
dc.format.extent | 15 | es |
dc.language.iso | eng | es |
dc.publisher | Impact Journals | es |
dc.relation.ispartof | Oncotarget, 8 (70), 1-15 p. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Wilms tumors | es |
dc.subject | Embryonic stem cell markers | es |
dc.subject | HMGA2 | es |
dc.subject | Blastemal stratification | es |
dc.title | HMGA2 overexpression predicts relapse susceptibility of blastemal Wilms tumor patients | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica | es |
dc.relation.publisherversion | 10.18632/oncotarget 23256 | es |
dc.identifier.doi | 10.18632/oncotarget 23256 | es |
dc.journaltitle | Oncotarget | es |
dc.publication.volumen | 8 | es |
dc.publication.issue | 70 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 15 | es |