dc.creator | Moura, David | es |
dc.creator | Fernández, Isabel | es |
dc.creator | Marín Royo, Gema | es |
dc.creator | López Sánchez, Inmaculada | es |
dc.creator | Martín Doncel, Elena | es |
dc.creator | Vega Moreno, Francisco Manuel | es |
dc.creator | Lazo, Pedro | es |
dc.creator | Martín Doncel, Elena | es |
dc.date.accessioned | 2020-04-29T16:31:57Z | |
dc.date.available | 2020-04-29T16:31:57Z | |
dc.date.issued | 2016-06-23 | |
dc.identifier.citation | Moura, D., Fernández, I., Marín Royo, G., López Sánchez, I., Martín Doncel, E., Vega Moreno, F.M.,...,Martín Doncel, E. (2016). Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation.. Scientific Reports, 6 | |
dc.identifier.issn | 2045-2322 | es |
dc.identifier.uri | https://hdl.handle.net/11441/95986 | |
dc.description.abstract | Sox2 is a pluripotency transcription factor that as an oncogene can also regulate cell proliferation.
Therefore, genes implicated in several different aspects of cell proliferation, such as the VRK1
chromatin-kinase, are candidates to be targets of Sox2. Sox 2 and VRK1 colocalize in nuclei of
proliferating cells forming a stable complex. Sox2 knockdown abrogates VRK1 gene expression.
Depletion of either Sox2 or VRK1 caused a reduction of cell proliferation. Sox2 up-regulates VRK1
expression and both proteins cooperate in the activation of CCND1. The accumulation of VRK1 protein
downregulates SOX2 expression and both proteins are lost in terminally differentiated cells. Induction
of neural differentiation with retinoic acid resulted in downregulation of Sox2 and VRK1 that inversely
correlated with the expression of differentiation markers such as N-cadherin, Pax6, mH2A1.2 and
mH2A2. Differentiation-associated macro histones mH2A1.2and mH2A2 inhibit CCND1 and VRK1
expression and also block the activation of the VRK1 promoter by Sox2. VRK1 is a downstream target of Sox2 and both form an autoregulatory loop in epithelial cell differentiation. | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad [SAF2013-44810R, SAF2014-57791-REDC]. | es |
dc.description.sponsorship | Consejería de Educación de la Junta de Castilla y León [CSI002U14 and UIC-017] to P.A.L. | es |
dc.format | application/pdf | es |
dc.format.extent | 15 | es |
dc.language.iso | eng | es |
dc.publisher | Nature Research | es |
dc.relation.ispartof | Scientific Reports, 6 | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Sox2 | es |
dc.subject | Cello proliferation | es |
dc.subject | VRK1 chromatin-kinase | es |
dc.title | Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation. | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica. | es |
dc.identifier.doi | 10.1038/srep28532 | es |
dc.journaltitle | Scientific Reports | es |
dc.publication.volumen | 6 | es |