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dc.contributor.advisor
dc.contributor.advisor
dc.contributor.advisor
dc.creatorAnnese, Valentinaes
dc.creatorNavarro Guerrero, Elenaes
dc.creatorRodríguez-Prieto, Ismaeles
dc.creatorPardal Redondo, Ricardoes
dc.date.accessioned2020-03-30T09:31:46Z
dc.date.available2020-03-30T09:31:46Z
dc.date.issued2017
dc.identifier.citationAnnese, V., Navarro Guerrero, E., Rodríguez-Prieto, I. y Pardal Redondo, R. (2017). Physiological Plasticity of Neural-Crest-Derived Stem Cells in the Adult Mammalian Carotid Body. Cell Reports, 19 (3), 471-478.
dc.identifier.issn2211-1247es
dc.identifier.urihttps://hdl.handle.net/11441/94671
dc.description.abstractAdult stem cell plasticity, or the ability of somatic stem cells to cross boundaries and differentiate into unrelated cell types, has been amatter of debate in the last decade. Neural-crest-derived stem cells (NCSCs) display a remarkable plasticity during development. Whether adult populations of NCSCs retain this plasticity is largely unknown. Herein, we describe that neural-crest-derived adult carotid body stem cells (CBSCs) are able to undergo endothelial differentiation in addition to their reported role in neurogenesis, contributing to both neurogenic and angiogenic processes taking place in the organ during acclimatization to hypoxia. Moreover, CBSC conversion into vascular cell types is hypoxia inducible factor (HIF) dependent and sensitive to hypoxiareleased vascular cytokines such as erythropoietin. Our data highlight a remarkable physiological plasticity in an adult population of tissue-specific stem cells and could have impact on the use of these cells for cell therapy.es
dc.description.sponsorshipERC Starting Grant: CBSCses
dc.description.sponsorshipMinisterio de Economía y Competitividad SAF2013-48535-P and SAF2016-80412-Pes
dc.formatapplication/pdfes
dc.format.extent9es
dc.language.isoenges
dc.publisherCell Presses
dc.relation.ispartofCell Reports, 19 (3), 471-478.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAngiogenesis and neurogenesises
dc.subjectCarotid body physiologyes
dc.subjectHypoxiaes
dc.subjectNeural-crest-derived adult stem cell plasticity and multipotencyes
dc.titlePhysiological Plasticity of Neural-Crest-Derived Stem Cells in the Adult Mammalian Carotid Bodyes
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Fisiología Médica y Biofísicaes
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.celrep.2017.03.065es
dc.identifier.doi10.1016/j.celrep.2017.03.065es
dc.contributor.groupUniversidad de Sevilla. CTS007: Fisiopatología de Células Madre Neuraleses
dc.journaltitleCell Reportses
dc.publication.volumen19es
dc.publication.issue3es
dc.publication.initialPage471es
dc.publication.endPage478es

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