dc.contributor.advisor | | |
dc.contributor.advisor | | |
dc.contributor.advisor | | |
dc.creator | Annese, Valentina | es |
dc.creator | Navarro Guerrero, Elena | es |
dc.creator | Rodríguez-Prieto, Ismael | es |
dc.creator | Pardal Redondo, Ricardo | es |
dc.date.accessioned | 2020-03-30T09:31:46Z | |
dc.date.available | 2020-03-30T09:31:46Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Annese, V., Navarro Guerrero, E., Rodríguez-Prieto, I. y Pardal Redondo, R. (2017). Physiological Plasticity of Neural-Crest-Derived Stem Cells in the Adult Mammalian Carotid Body. Cell Reports, 19 (3), 471-478. | |
dc.identifier.issn | 2211-1247 | es |
dc.identifier.uri | https://hdl.handle.net/11441/94671 | |
dc.description.abstract | Adult stem cell plasticity, or the ability of somatic
stem cells to cross boundaries and differentiate
into unrelated cell types, has been amatter of debate
in the last decade. Neural-crest-derived stem cells
(NCSCs) display a remarkable plasticity during
development. Whether adult populations of NCSCs
retain this plasticity is largely unknown. Herein, we
describe that neural-crest-derived adult carotid
body stem cells (CBSCs) are able to undergo endothelial
differentiation in addition to their reported
role in neurogenesis, contributing to both neurogenic
and angiogenic processes taking place in the organ
during acclimatization to hypoxia. Moreover, CBSC
conversion into vascular cell types is hypoxia inducible
factor (HIF) dependent and sensitive to hypoxiareleased
vascular cytokines such as erythropoietin.
Our data highlight a remarkable physiological plasticity
in an adult population of tissue-specific stem
cells and could have impact on the use of these cells
for cell therapy. | es |
dc.description.sponsorship | ERC Starting Grant: CBSCs | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad SAF2013-48535-P and SAF2016-80412-P | es |
dc.format | application/pdf | es |
dc.format.extent | 9 | es |
dc.language.iso | eng | es |
dc.publisher | Cell Press | es |
dc.relation.ispartof | Cell Reports, 19 (3), 471-478. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Angiogenesis and neurogenesis | es |
dc.subject | Carotid body physiology | es |
dc.subject | Hypoxia | es |
dc.subject | Neural-crest-derived adult stem cell plasticity and multipotency | es |
dc.title | Physiological Plasticity of Neural-Crest-Derived Stem Cells in the Adult Mammalian Carotid Body | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.celrep.2017.03.065 | es |
dc.identifier.doi | 10.1016/j.celrep.2017.03.065 | es |
dc.contributor.group | Universidad de Sevilla. CTS007: Fisiopatología de Células Madre Neurales | es |
dc.journaltitle | Cell Reports | es |
dc.publication.volumen | 19 | es |
dc.publication.issue | 3 | es |
dc.publication.initialPage | 471 | es |
dc.publication.endPage | 478 | es |