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dc.creatorGarcía Rondón, Anaes
dc.creatorAguilera López, Andréses
dc.date.accessioned2020-02-18T11:12:55Z
dc.date.available2020-02-18T11:12:55Z
dc.date.issued2019
dc.identifier.citationGarcía Rondón, A. y Aguilera López, A. (2019). What causes an RNA-DNA hybrid to compromise genome integrity?. DNA Repair, 81, 102660.
dc.identifier.issn1568-7864es
dc.identifier.urihttps://hdl.handle.net/11441/93311
dc.description.abstractTranscription is a source of genome instability that stimulates mutation and recombination. Part of the damage produced by transcription is mediated by R-loops, non-B DNA structures that normally form by the re-annealing of the nascent RNA with the template DNA outside the catalytic center of the RNA polymerase, displacing the non-template strand. Recent discoveries have revealed that R-loops might not be harmful by themselves. Instead, chromatin compaction triggered by these structures seems necessary, as deduced from the histone modifications frequently found associated with harmful R-loops. Remarkably, hybrids may also become harmful if stabilized by specific RNA binding proteins, one example of which is the yeast Yra1. We discuss here the possible mechanisms by which cells may stabilize R-loops and the consequences on transcription-replication conflicts and telomere homeostasis.es
dc.description.sponsorshipEuropean Research Counciles
dc.description.sponsorshipMinisterio de Ciencia e Innovaciónes
dc.description.sponsorshipJunta de Andalucíaes
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherElsevieres
dc.relation.ispartofDNA Repair, 81, 102660.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectR-loopses
dc.subjectYra1es
dc.subjectALY/REFes
dc.subjectTranscription replication conflictses
dc.subjectTelomereses
dc.subjectRNA-DNA hybrid bindinges
dc.titleWhat causes an RNA-DNA hybrid to compromise genome integrity?es
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/acceptedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Genéticaes
dc.relation.publisherversionhttps://doi.org/10.1016/j.dnarep.2019.102660es
dc.identifier.doi10.1016/j.dnarep.2019.102660es
idus.format.extent4 p.es
dc.journaltitleDNA Repaires
dc.publication.volumen81es
dc.publication.initialPage102660es

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