dc.creator | García Muse, Tatiana | es |
dc.creator | Aguilera López, Andrés | es |
dc.date.accessioned | 2020-02-18T10:48:07Z | |
dc.date.available | 2020-02-18T10:48:07Z | |
dc.date.issued | 2019-10-17 | |
dc.identifier.citation | García Muse, T. y Aguilera López, A. (2019). R Loops: From Physiologicalto Pathological Roles. Cell, 179 (3), 604-618. | |
dc.identifier.issn | 0092-8674 | es |
dc.identifier.uri | https://hdl.handle.net/11441/93300 | |
dc.description.abstract | DNA-RNA hybrids play a physiological role in cellular processes, but often, they represent non-scheduled co-transcriptional structures with a negative impact on transcription, replication and DNA repair. Accumulating evidence suggests that they constitute a source of replication stress, DNA breaks and genome instability. Reciprocally, DNA breaks facilitate DNA-RNA hybrid formation by releasing the double helix torsional conformation. Cells avoid DNA-RNA accumulation by either preventing or removing hybrids directly or by DNA repair-coupled mechanisms. Given the R-loop impact on chromatin and genome organization and its potential relation with genetic diseases, we review R-loop homeostasis as well as their physiological and pathological roles. | es |
dc.description.sponsorship | European Research Council (ERC2014 AdG669898 TARLOOP) | es |
dc.description.sponsorship | Junta de Andalucía (BIO1238) | es |
dc.description.sponsorship | European Union Regional Funds (FEDER) | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Cell, 179 (3), 604-618. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | R-loop | es |
dc.title | R Loops: From Physiologicalto Pathological Roles | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Genética | es |
dc.relation.projectID | ERC2014 AdG669898 TARLOOP | es |
dc.relation.projectID | BFU2016-75058-P | es |
dc.relation.projectID | BIO1238 | es |
dc.relation.publisherversion | https://doi.org/10.1016/j.cell.2019.08.055 | es |
dc.identifier.doi | 10.1016/j.cell.2019.08.055 | es |
idus.format.extent | 14 p. | es |
dc.journaltitle | Cell | es |
dc.publication.volumen | 179 | es |
dc.publication.issue | 3 | es |
dc.publication.initialPage | 604 | es |
dc.publication.endPage | 618 | es |