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P450BM3-Catalyzed Oxidations Employing Dual Functional Small Molecules

dc.creatorWillot, Sébastien Jean-Paules
dc.creatorTieves, Florianes
dc.creatorGirhard, Marcoes
dc.creatorUrlacher, Vlada B.es
dc.creatorHollmann, Frankes
dc.creatorGonzalo Calvo, Gonzalo dees
dc.date.accessioned2019-08-23T11:29:10Z
dc.date.available2019-08-23T11:29:10Z
dc.date.issued2019
dc.identifier.citationWillot, S.J., Tieves, F., Girhard, M., Urlacher, V.B., Hollmann, F. y Gonzalo Calvo, G.d. (2019). P450BM3-Catalyzed Oxidations Employing Dual Functional Small Molecules. Catalysts, 9 (7), 567-1-567-9.
dc.identifier.issn2073-4344es
dc.identifier.urihttps://hdl.handle.net/11441/88633
dc.description.abstractA set of dual functional small molecules (DFSMs) containing different amino acids has been synthesized and employed together with three different variants of the cytochrome P450 monooxygenase P450BM3 from Bacillus megaterium in H2O2-dependent oxidation reactions. These DFSMs enhance P450BM3 activity with hydrogen peroxide as an oxidant, converting these enzymes into formal peroxygenases. This system has been employed for the catalytic epoxidation of styrene and in the sulfoxidation of thioanisole. Various P450BM3 variants have been evaluated in terms of activity and selectivity of the peroxygenase reactions.es
dc.description.sponsorshipMINECO-CTQ2016-76908-C2-1,2-Pes
dc.description.sponsorshipComisión Europea de Investigación-ERC-648026es
dc.description.sponsorshipUnión Europea-H2020-BBI-PPP-2015-2-1-720297es
dc.description.sponsorshipOrganización Holandesa de Investigación Científica (VICI)-724.014.003es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherMDPIes
dc.relation.ispartofCatalysts, 9 (7), 567-1-567-9.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBiocatalysises
dc.subjectCytochrome P450es
dc.subjectDual functional small moleculeses
dc.subjectEpoxidationses
dc.subjectSulfoxidationes
dc.titleP450BM3-Catalyzed Oxidations Employing Dual Functional Small Moleculeses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Química orgánicaes
dc.relation.projectIDCTQ2016-76908-C2-1,2-Pes
dc.relation.projectIDERC-648026es
dc.relation.projectIDH2020-BBI-PPP-2015-2-1-720297es
dc.relation.projectIDVICI-724.014.003es
dc.relation.publisherversionhttps://doi.org/10.3390/catal9070567es
dc.identifier.doi10.3390/catal9070567es
idus.format.extent9 p.es
dc.journaltitleCatalystses
dc.publication.volumen9es
dc.publication.issue7es
dc.publication.initialPage567-1es
dc.publication.endPage567-9es

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