Artículo
Intracellular Trafficking and Persistence of Acinetobacter baumannii Requires Transcription Factor EB
Autor/es | Parra Millán, Raquel
Guerrero Gómez, David Ayerbe Algaba, Rafael Pachón Ibáñez, María Eugenia Miranda Vizuete, Antonio Pachón Díaz, Jerónimo Smani, Younes |
Departamento | Instituto de Biomedicina de Sevilla (IBIS) |
Fecha de publicación | 2018-03-28 |
Fecha de depósito | 2018-05-25 |
Publicado en |
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Resumen | Acinetobacter baumannii is a significant human pathogen associated with hospital-acquired infections. While adhesion, an initial and important step in A. baumannii infection, is well characterized, the intracellular ... Acinetobacter baumannii is a significant human pathogen associated with hospital-acquired infections. While adhesion, an initial and important step in A. baumannii infection, is well characterized, the intracellular trafficking of this pathogen inside host cells remains poorly studied. Here, we demonstrate that transcription factor EB (TFEB) is activated after A. baumannii infection of human lung epithelial cells (A549). We also show that TFEB is required for the invasion and persistence inside A549 cells. Consequently, lysosomal biogenesis and autophagy activation were observed after TFEB activation which could increase the death of A549 cells. In addition, using the Caenorhabditis elegans infection model by A. baumannii, the TFEB orthologue HLH-30 was required for survival of the nematode to infection, although nuclear translocation of HLH-30 was not required. These results identify TFEB as a conserved key factor in the pathogenesis of A. baumannii. |
Identificador del proyecto | Consejería de Innovación, Ciencia y Empresa CTS 6317/11
Instituto de Salud Carlos III PI13/01744 CP15/00132 PI15/01358 Ministerio de Economía, Industria y Competitividad. Subdirección General de Redes y Centros de Investigación Cooperativa PI13/01744 CP15/00132 PI15/01358 Spanish Ministry of Economy and Competitiveness BFU2015-64408-P |
Cita | Parra Millán, R., Guerrero Gómez, D., Ayerbe Algaba, R., Pachón Ibáñez, M.E., Miranda Vizuete, A., Pachón Díaz, J. y Smani, Y. (2018). Intracellular Trafficking and Persistence of Acinetobacter baumannii Requires Transcription Factor EB. mSphere, 3 (2), 00106-18-1-00106-18-14. |
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