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dc.creatorMillán Linares, María del Carmenes
dc.creatorBermúdez Pulgarín, Beatrizes
dc.creatorYust Escobar, María del Mares
dc.creatorMillán, Franciscoes
dc.creatorPedroche, Justoes
dc.date.accessioned2017-09-13T14:02:13Z
dc.date.available2017-09-13T14:02:13Z
dc.date.issued2014
dc.identifier.citationMillán Linares, M.d.C., Bermúdez Pulgarín, B., Yust Escobar, M.d.M., Millán, F. y Pedroche, J. (2014). Anti-inflammatory activity of lupine (Lupinus angustifolius L.) protein hydrolysates in THP-1-derived macrophages. Journal of Functional Foods, 8, 224-233.
dc.identifier.issn1756-4646es
dc.identifier.urihttp://hdl.handle.net/11441/64412
dc.description.abstractThe effect of two different lupine protein hydrolysates (LPHs) on in vitro macrophage activation in a THP-1-derived macrophage model was investigated. THP-1-derived macrophages were exposed to RPMI medium containing two LPHs obtained by enzymatic hydrolysis using two different proteases: Izyme AL and Alcalase 2.4 L. Cytokine's expression was measured by quantitative PCR. THP-1-derived macrophages exhibited attenuated expression of proinflammatory cytokines (tumor necrosis factor (TNF), IL-6, IL-1β) and increased expression of anti-inflammatory marker genes (chemokine (C-C motif) ligand 18 (CCL18)) relative to control without LPH. The anti-inflammatory effect of both hydrolysates favored M2 polarization by quenching C-C chemokine receptor type 2 (CCR2) expression and migratory capacity. Furthermore, LPHs significantly decreased nitric oxide production. Moreover, LPHs promoted the survival of human THP-1-derived macrophages. Therefore, inclusion of LPHs in foods may help to prevent chronic diseases associated with chronic inflammation.es
dc.description.sponsorshipMinisterio de Economía y Competitividad AGL2012–40247-C02-01es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherElsevieres
dc.relation.ispartofJournal of Functional Foods, 8, 224-233.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectLupine protein hydrolysateses
dc.subjectMacrophage polarizationes
dc.subjectAnti-inflammatory activityes
dc.subjectBioactive peptideses
dc.titleAnti-inflammatory activity of lupine (Lupinus angustifolius L.) protein hydrolysates in THP-1-derived macrophageses
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/submittedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Ingeniería Químicaes
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/AGL2012–40247-C02-01es
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.jff.2014.03.020es
dc.identifier.doi10.1016/j.jff.2014.03.020es
idus.format.extent31 p.es
dc.journaltitleJournal of Functional Foodses
dc.publication.volumen8es
dc.publication.initialPage224es
dc.publication.endPage233es
dc.contributor.funderMinisterio de Economía y Competitividad (MINECO). España

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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