dc.creator | Guzmán Guillén, Remedios | es |
dc.creator | Puerto Rodríguez, María | es |
dc.creator | Gutiérrez-Praena, Daniel | es |
dc.creator | Prieto Ortega, Ana Isabel | es |
dc.creator | Pichardo Sánchez, Silvia | es |
dc.creator | Jos Gallego, Ángeles Mencía | es |
dc.creator | Campos, Alexandre | es |
dc.creator | Vasconcelos, Vitor | es |
dc.creator | Cameán Fernández, Ana María | es |
dc.date.accessioned | 2017-09-05T15:11:27Z | |
dc.date.available | 2017-09-05T15:11:27Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Guzmán Guillén, R., Puerto Rodríguez, M., Gutiérrez Praena, D., Prieto Ortega, A.I., Pichardo Sánchez, S., Jos Gallego, Á.M.,...,Cameán Fernández, A.M. (2017). Potential use of chemoprotectants against the toxic effects of cyanotoxins: A review. Toxins, 9 (6), 1-36. | |
dc.identifier.issn | 2072-6651 (electrónico) | es |
dc.identifier.uri | http://hdl.handle.net/11441/64193 | |
dc.description.abstract | Cyanobacterial toxins, particularly microcystins (MCs) and cylindrospermopsin (CYN),
are responsible for toxic effects in humans and wildlife. In order to counteract or prevent their
toxicity, various strategies have been followed, such as the potential application of chemoprotectants.
A review of the main substances evaluated for this aim, as well as the doses and their influence
on cyanotoxin-induced toxicity, has been performed. A search of the literature shows that research
on MCs is much more abundant than research on CYN. Among chemoprotectants, antioxidant
compounds are the most extensively studied, probably because it is well known that oxidative stress
is one of the toxic mechanisms common to both toxins. In this group, vitamin E seems to have the
strongest protectant effect for both cyanotoxins. Transport inhibitors have also been studied in the
case of MCs, as CYN cellular uptake is not yet fully elucidated. Further research is needed because
systematic studies are lacking. Moreover, more realistic exposure scenarios, including cyanotoxin
mixtures and the concomitant use of chemoprotectants, should be considered. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Toxins, 9 (6), 1-36. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Microcystins | es |
dc.subject | Cylindrospermopsin | es |
dc.subject | Chemoprotection | es |
dc.subject | Transport inhibitors | es |
dc.subject | Antioxidant substances | es |
dc.title | Potential use of chemoprotectants against the toxic effects of cyanotoxins: A review | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal | es |
dc.relation.publisherversion | http://dx.doi.org/ 10.3390/toxins9060175 | es |
dc.identifier.doi | 10.3390/toxins9060175 | es |
idus.format.extent | 36 p. | es |
dc.journaltitle | Toxins | es |
dc.publication.volumen | 9 | es |
dc.publication.issue | 6 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 36 | es |