Article
Role for neonatal D-serine signaling: prevention of physiological and behavioral deficits in adult Pick1 knockout mice
Author/s | Nomura, Jun
Jaaro Peled, Hanna Lewis, Eastman Núñez Abades, Pedro Antonio |
Department | Universidad de Sevilla. Departamento de Fisiología |
Publication Date | 2016 |
Deposit Date | 2017-06-05 |
Published in |
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Abstract | NMDA glutamate receptors play key roles in brain development, function, and dysfunction. Regulatory roles of D-serine in NMDA receptor-mediated synaptic plasticity have been reported. Nonetheless, it is unclear whether and ... NMDA glutamate receptors play key roles in brain development, function, and dysfunction. Regulatory roles of D-serine in NMDA receptor-mediated synaptic plasticity have been reported. Nonetheless, it is unclear whether and how neonatal deficits in NMDA-receptor-mediated neurotransmission affect adult brain functions and behavior. Likewise, the role of D-serine during development remains elusive. Here we report behavioral and electrophysiological deficits associated with the frontal cortex in Pick1 knockout mice, which show D-serine deficits in a neonatal and forebrain specific manner. The pathological manifestations observed in adult Pick1 mice are rescued by transient neonatal supplementation of D-serine, but not by a similar treatment in adulthood. These results indicate a role for D-serine in neurodevelopment and provide novel insights on how we interpret data of psychiatric genetics, indicating the involvement of genes associated with D-serine synthesis and degradation, as well as how we consider animal models with neonatal application of NMDA receptor antagonists |
Citation | Nomura, J., Jaaro Peled, H., Lewis, y Nuñez Abades, P.A. (2016). Role for neonatal D-serine signaling: prevention of physiological and behavioral deficits in adult Pick1 knockout mice. Molecular Psychiatry, 21 (3), 386-393. |
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