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Role for neonatal D-serine signaling: prevention of physiological and behavioral deficits in adult Pick1 knockout mice
dc.creator | Nomura, Jun | es |
dc.creator | Jaaro Peled, Hanna | es |
dc.creator | Lewis, Eastman | es |
dc.creator | Núñez Abades, Pedro Antonio | es |
dc.date.accessioned | 2017-06-05T11:30:20Z | |
dc.date.available | 2017-06-05T11:30:20Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Nomura, J., Jaaro Peled, H., Lewis, y Nuñez Abades, P.A. (2016). Role for neonatal D-serine signaling: prevention of physiological and behavioral deficits in adult Pick1 knockout mice. Molecular Psychiatry, 21 (3), 386-393. | |
dc.identifier.issn | 1359-4184 | es |
dc.identifier.uri | http://hdl.handle.net/11441/60917 | |
dc.description.abstract | NMDA glutamate receptors play key roles in brain development, function, and dysfunction. Regulatory roles of D-serine in NMDA receptor-mediated synaptic plasticity have been reported. Nonetheless, it is unclear whether and how neonatal deficits in NMDA-receptor-mediated neurotransmission affect adult brain functions and behavior. Likewise, the role of D-serine during development remains elusive. Here we report behavioral and electrophysiological deficits associated with the frontal cortex in Pick1 knockout mice, which show D-serine deficits in a neonatal and forebrain specific manner. The pathological manifestations observed in adult Pick1 mice are rescued by transient neonatal supplementation of D-serine, but not by a similar treatment in adulthood. These results indicate a role for D-serine in neurodevelopment and provide novel insights on how we interpret data of psychiatric genetics, indicating the involvement of genes associated with D-serine synthesis and degradation, as well as how we consider animal models with neonatal application of NMDA receptor antagonists | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Nature Publishing Group | es |
dc.relation.ispartof | Molecular Psychiatry, 21 (3), 386-393. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | PICK1 | es |
dc.subject | D-serine | es |
dc.subject | NMDA | es |
dc.subject | developmental trajectory | es |
dc.subject | prefrontal cortex | es |
dc.subject | prepulse inhibition | es |
dc.title | Role for neonatal D-serine signaling: prevention of physiological and behavioral deficits in adult Pick1 knockout mice | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/submittedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología | es |
dc.relation.publisherversion | http://dx.doi.org/10.1038/mp.2015.61 | es |
dc.identifier.doi | 10.1038/mp.2015.61 | es |
idus.format.extent | 8 p. | es |
dc.journaltitle | Molecular Psychiatry | es |
dc.publication.volumen | 21 | es |
dc.publication.issue | 3 | es |
dc.publication.initialPage | 386 | es |
dc.publication.endPage | 393 | es |
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pub2nihms659610.pdf | 1015.Kb | [PDF] | Ver/ | |