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dc.creatorNomura, Junes
dc.creatorJaaro Peled, Hannaes
dc.creatorLewis, Eastmanes
dc.creatorNúñez Abades, Pedro Antonioes
dc.date.accessioned2017-06-05T11:30:20Z
dc.date.available2017-06-05T11:30:20Z
dc.date.issued2016
dc.identifier.citationNomura, J., Jaaro Peled, H., Lewis, y Nuñez Abades, P.A. (2016). Role for neonatal D-serine signaling: prevention of physiological and behavioral deficits in adult Pick1 knockout mice. Molecular Psychiatry, 21 (3), 386-393.
dc.identifier.issn1359-4184es
dc.identifier.urihttp://hdl.handle.net/11441/60917
dc.description.abstractNMDA glutamate receptors play key roles in brain development, function, and dysfunction. Regulatory roles of D-serine in NMDA receptor-mediated synaptic plasticity have been reported. Nonetheless, it is unclear whether and how neonatal deficits in NMDA-receptor-mediated neurotransmission affect adult brain functions and behavior. Likewise, the role of D-serine during development remains elusive. Here we report behavioral and electrophysiological deficits associated with the frontal cortex in Pick1 knockout mice, which show D-serine deficits in a neonatal and forebrain specific manner. The pathological manifestations observed in adult Pick1 mice are rescued by transient neonatal supplementation of D-serine, but not by a similar treatment in adulthood. These results indicate a role for D-serine in neurodevelopment and provide novel insights on how we interpret data of psychiatric genetics, indicating the involvement of genes associated with D-serine synthesis and degradation, as well as how we consider animal models with neonatal application of NMDA receptor antagonistses
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherNature Publishing Groupes
dc.relation.ispartofMolecular Psychiatry, 21 (3), 386-393.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPICK1es
dc.subjectD-serinees
dc.subjectNMDAes
dc.subjectdevelopmental trajectoryes
dc.subjectprefrontal cortexes
dc.subjectprepulse inhibitiones
dc.titleRole for neonatal D-serine signaling: prevention of physiological and behavioral deficits in adult Pick1 knockout micees
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/submittedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Fisiologíaes
dc.relation.publisherversionhttp://dx.doi.org/10.1038/mp.2015.61es
dc.identifier.doi10.1038/mp.2015.61es
idus.format.extent8 p.es
dc.journaltitleMolecular Psychiatryes
dc.publication.volumen21es
dc.publication.issue3es
dc.publication.initialPage386es
dc.publication.endPage393es

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