dc.creator | Jiménez Blanco, José Luis | es |
dc.creator | Ortega Caballero, Fernando | es |
dc.creator | Ortiz Mellet, Carmen | es |
dc.creator | García Fernández, José Manuel | es |
dc.date.accessioned | 2017-04-24T10:26:33Z | |
dc.date.available | 2017-04-24T10:26:33Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | Jiménez Blanco, J.L., Ortega Caballero, F., Ortiz Mellet, C. y García Fernández, J.M. (2010). (Pseudo)amide-linked oligosaccharide mimetics: molecular recognition and supramolecular properties. Beilstein Journal of Organic Chemistry, 6 (20), 1-18. | |
dc.identifier.issn | 1860-539 | es |
dc.identifier.uri | http://hdl.handle.net/11441/58270 | |
dc.description.abstract | Oligosaccharides are currently recognised as having functions that influence the entire spectrum of cell activities. However, a distinct disadvantage of naturally occurring oligosaccharides is their metabolic instability in biological systems. Therefore, much effort has been spent in the past two decades on the development of feasible routes to carbohydrate mimetics which can compete with their O-glycosidic counterparts in cell surface adhesion, inhibit carbohydrate processing enzymes, and interfere in the biosynthesis of specific cell surface carbohydrates. Such oligosaccharide mimetics are potential therapeutic agents against HIV and other infections, against cancer, diabetes and other metabolic diseases. An efficient strategy to access this type of compounds is the replacement of the glycosidic linkage by amide or pseudoamide functions such as thiourea, urea and guanidine. In this review we summarise the advances over the last decade in the synthesis of oligosaccharide mimetics that possess amide and pseudoamide linkages, as well as studies focussing on their supramolecular and recognition properties | es |
dc.description.sponsorship | España , Ministerio de Ciencia e Innovación CTQ2007-6118/PPQ | es |
dc.description.sponsorship | España, Ministerio de Ciencia e innovación CTQ2009-14551-C02-01 | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Beilstein-Institut | es |
dc.relation.ispartof | Beilstein Journal of Organic Chemistry, 6 (20), 1-18. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | carbopeptoids | es |
dc.subject | glycoclusters | es |
dc.subject | glycomimetics | es |
dc.subject | pseudooligosaccharides | es |
dc.subject | spaced sugars | es |
dc.title | (Pseudo)amide-linked oligosaccharide mimetics: molecular recognition and supramolecular properties | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química orgánica | es |
dc.relation.projectID | CTQ2007-6118/PPQ | es |
dc.relation.projectID | CTQ2009-14551-C02-01 | es |
dc.relation.publisherversion | http://dx.doi.org/10.3762/bjoc.6.20 | es |
dc.identifier.doi | 10.3762/bjoc.6.20 | es |
idus.format.extent | 19 p. | es |
dc.journaltitle | Beilstein Journal of Organic Chemistry | es |
dc.publication.volumen | 6 | es |
dc.publication.issue | 20 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 18 | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | |