dc.creator | Medina, Daniel A. | es |
dc.creator | Jordán Pla, Antonio | es |
dc.creator | Millán Zambrano, Gonzalo | es |
dc.creator | Chávez de Diego, Sebastián | es |
dc.creator | Pérez Ortín, José E. | es |
dc.date.accessioned | 2017-03-08T14:23:23Z | |
dc.date.available | 2017-03-08T14:23:23Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Medina, D.A., Jordán Pla, A., Millán Zambrano, G., Chávez de Diego, S. y Pérez Ortín, .E. (2014). Cytoplasmic 5′-3′ exonuclease Xrn1p is also a genome-wide transcription factor in yeast. Frontiers in genetics, 5 (1), 1-10. | |
dc.identifier.issn | 1664-8021 | es |
dc.identifier.uri | http://hdl.handle.net/11441/55590 | |
dc.description.abstract | The 5′ to 3′ exoribonuclease Xrn1 is a large protein involved in cytoplasmatic mRNA degradation as a critical component of the major decaysome. Its deletion in the yeast Saccharomyces cerevisiae is not lethal, but it has multiple physiological effects. In a previous study, our group showed that deletion of all tested components of the yeast major decaysome, including XRN1, results in a decrease in the synthetic rate and an increase in half-life of most mRNAs in a compensatory manner. Furthermore, the same study showed that the all tested decaysome components are also nuclear proteins that bind to the 5′ region of a number of genes. In the present work, we show that disruption of Xrn1 activity preferentially affects both the synthesis and decay of a distinct subpopulation of mRNAs. The most affected mRNAs are the transcripts of the highly transcribed genes, mainly those encoding ribosome biogenesis and translation factors. Previously, we proposed that synthegradases play a key role in regulating both mRNA synthesis and degradation. Evidently, Xrn1 functions as a synthegradase, whose selectivity might help coordinating the expression of the protein synthetic machinery. We propose to name the most affected genes “Xrn1 synthegradon.” | es |
dc.description.sponsorship | España , Ministerio de Ciencia e Innovación BFU2010-21975-C03-01 | es |
dc.description.sponsorship | España , Ministerio de Ciencia e Innovación BFU2010-21975-C03-02 | es |
dc.description.sponsorship | España, Andalucia, Junta P07-CVI-02623 | es |
dc.description.sponsorship | España, Andalucia, Junta P08-CVI-03508 | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Frontiers Media | es |
dc.relation.ispartof | Frontiers in genetics, 5 (1), 1-10. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | transcription rate | es |
dc.subject | nascent transcription | es |
dc.subject | mRNA synthesis | es |
dc.subject | mRNA decay | es |
dc.subject | mRNA stability | es |
dc.title | Cytoplasmic 5′-3′ exonuclease Xrn1p is also a genome-wide transcription factor in yeast | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Genética | es |
dc.relation.projectID | BFU2010-21975-C03-01 | es |
dc.relation.projectID | BFU2010-21975-C03-02 | es |
dc.relation.projectID | P07-CVI-02623 | es |
dc.relation.projectID | P08-CVI-03508 | es |
dc.relation.publisherversion | http://dx.doi.org/10.3389/fgene.2014.00001 | es |
dc.identifier.doi | 10.3389/fgene.2014.00001 | es |
idus.format.extent | 11 p. | es |
dc.journaltitle | Frontiers in genetics | es |
dc.publication.volumen | 5 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 10 | es |