Artículo
Functional Diversity of Neurotrophin Actions on the Oculomotor System
Autor/es | Benítez Temiño, Beatriz
Davis López de Carrizosa, María América Morcuende Fernández, Sara R. Rodríguez Matarredona, Esperanza Rodríguez de la Cruz, Rosa María Pastor Loro, Ángel Manuel |
Departamento | Universidad de Sevilla. Departamento de Fisiología |
Fecha de publicación | 2016 |
Fecha de depósito | 2017-01-17 |
Publicado en |
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Resumen | Neurotrophins play a principal role in neuronal survival and differentiation during development, but also in the maintenance of appropriate adult neuronal circuits and phenotypes. In the oculomotor system, we have demonstrated ... Neurotrophins play a principal role in neuronal survival and differentiation during development, but also in the maintenance of appropriate adult neuronal circuits and phenotypes. In the oculomotor system, we have demonstrated that neurotrophins are key regulators of developing and adult neuronal properties, but with peculiarities depending on each neurotrophin. For instance, the administration of NGF, BDNF or NT-3 protects neonatal extraocular motoneurons from cell death after axotomy, but only NGF and BDNF prevent the downregulation in ChAT. In the adult, in vivo recordings of axotomized extraocular motoneurons have demonstrated that the delivery of NGF, BDNF or NT-3 recovers different components of the firing discharge activity of these cells, with some particularities in the case of NGF. All neurotrophins have also synaptotrophic activity, although to different degrees. Accordingly, neurotrophins can restore the axotomy-induced alterations acting selectively on different properties of the motoneuron. In this review we summarize these evidences and discuss them in the context of other motor systems. |
Agencias financiadoras | Ministerio de Economía y Competitividad (MINECO). España Junta de Andalucía |
Identificador del proyecto | info:eu-repo/grantAgreement/MINECO/BFU2009-07121
info:eu-repo/grantAgreement/MINECO/BFU2012-33975 info:eu-repo/grantAgreement/MINECO/BFU2015-64515-P CVI-6053 |
Cita | Benítez Temiño, B., Davis López de Carrizosa, M.A., Morcuende Fernández, S.R., Matarredonda, E.R., Cruz, R.R.d.l. y Pastor Loro, Á.M. (2016). Functional Diversity of Neurotrophin Actions on the Oculomotor System. International Journal of Molecular Sciences, 17 (12) |
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Funtional Diversity.pdf | 1.992Mb | [PDF] | Ver/ | |