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Artículo
Acute oxygen sensing in heme oxygenase-2 null mice
dc.creator | Ortega Sáenz, Patricia | |
dc.creator | López Barneo, José | |
dc.creator | Pascual Bravo, Alberto | |
dc.creator | Gómez Díaz, Raquel | |
dc.date.accessioned | 2015-01-16T13:22:15Z | |
dc.date.available | 2015-01-16T13:22:15Z | |
dc.date.issued | 2006 | |
dc.identifier.issn | 1540-7748 | es |
dc.identifier.issn | 0022-1295 | es |
dc.identifier.uri | http://hdl.handle.net/11441/17808 | |
dc.description.abstract | Hemeoxygenase-2 (HO-2) is an antioxidant enzyme that can modulate recombinant maxi-K+ channels and has been proposed to be the acute O2 sensor in the carotid body (CB). We have tested the physiological contribution of this enzyme to O2 sensing using HO-2 null mice. HO-2 deficiency leads to a CB phenotype characterized by organ growth and alteration in the expression of stress-dependent genes, including the maxi-K+ channel α-subunit. However, sensitivity to hypoxia of CB is remarkably similar in HO-2 null animals and their control littermates. Moreover, the response to hypoxia in mouse and rat CB cells was maintained after blockade of maxi-K+ channels with iberiotoxin. Hypoxia responsiveness of the adrenal medulla (AM) (another acutely responding O2-sensitive organ) was also unaltered by HO-2 deficiency. Our data suggest that redox disregulation resulting from HO-2 deficiency affects maxi-K+ channel gene expression but it does not alter the intrinsic O2 sensitivity of CB or AM cells. Therefore, HO-2 is not a universally used acute O2 sensor. | es |
dc.language.iso | eng | es |
dc.relation.ispartof | The Journal of general physiology, 128 (4), 405-411. | es |
dc.rights | Atribución-NoComercial-SinDerivadas 4.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Acute oxygen sensing in heme oxygenase-2 null mice | |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.journaltitle | The Journal of general physiology | es |
dc.publication.volumen | 128 | es |
dc.publication.issue | 4 | es |
dc.publication.initialPage | 405 | es |
dc.publication.endPage | 411 | es |
dc.identifier.idus | https://idus.us.es/xmlui/handle/11441/17808 |
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