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Artículo
Thyrotropin-releasing-hormone (TRH) and its physiological metabolite TRH-OH inhibit Na+ channel activity in mammalian septal neurons
dc.creator | López Barneo, José | |
dc.creator | Castellano Orozco, Antonio Gonzalo | |
dc.creator | Toledo Aral, Juan José | |
dc.date.accessioned | 2015-01-14T13:53:24Z | |
dc.date.available | 2015-01-14T13:53:24Z | |
dc.date.issued | 1990 | |
dc.identifier.citation | López Barneo, J., Castellano Orozco, A.G. y Toledo Aral, J.J. (1990). Thyrotropin-releasing-hormone (TRH) and its physiological metabolite TRH-OH inhibit Na+ channel activity in mammalian septal neurons. Proceedings of the National Academy of Sciences of the United States of America, 87 (20), 8150-8154. | |
dc.identifier.issn | 1091-6490 | es |
dc.identifier.uri | http://hdl.handle.net/11441/17483 | |
dc.description.abstract | The interaction of thyrotropin-releasing hormone (TRH) and its physiological metabolite TRH-OH with Na+ channels was studied in enzymatically dissociated guinea pig septal neurons by using the whole-cell variant of the patch-clamp technique. In about 60% of the cells tested, the neuropeptides at concentrations between 0.01 and 2.5 ,uM produced a dose-dependent reversible attenuation of Na+ currents. With 2 ,uM TRH-OH, peak Na+ current amplitude was reduced by 20-50% (27 ± 8%, mean ± SD; n = 16), whereas at the same concentration TRH was approximately half as effective as TRH-OH. In the presence of the tripeptides, the voltage-dependent parameters of the Na+ current were unaltered. TRH-induced reduction of Na+ current amplitude was transient and recovered almost completely during maintained exposure to the peptides. In addition, the response to either TRH-OH or TRH decreased with repeated treatment. Our results demonstrate that neuronal Na+ channels can be modulated by naturally occurring neuropeptides. | es |
dc.language.iso | eng | es |
dc.language.iso | deu | es |
dc.language.iso | fra | es |
dc.language.iso | ita | es |
dc.language.iso | jpn | es |
dc.relation.ispartof | Proceedings of the National Academy of Sciences of the United States of America, 87 (20), 8150-8154. | es |
dc.rights | Atribución-NoComercial-SinDerivadas 4.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Thyrotropin-releasing-hormone (TRH) and its physiological metabolite TRH-OH inhibit Na+ channel activity in mammalian septal neurons | es |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.relation.publisherversion | http://dx.doi.org/10.1073/pnas.87.20.8150 | |
dc.identifier.doi | 10.1073/pnas.87.20.8150 | |
dc.journaltitle | Proceedings of the National Academy of Sciences of the United States of America | es |
dc.publication.volumen | 87 | es |
dc.publication.issue | 20 | es |
dc.publication.initialPage | 8150 | es |
dc.publication.endPage | 8154 | es |
dc.identifier.idus | https://idus.us.es/xmlui/handle/11441/17483 |
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