dc.creator | Rodríguez Salamanca, Patricia | es |
dc.creator | Fernández Fernández, Rosario Fátima | es |
dc.creator | Hornillos, Valentín | es |
dc.creator | Lassaletta, José M. | es |
dc.date.accessioned | 2024-08-30T13:57:31Z | |
dc.date.available | 2024-08-30T13:57:31Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Rodríguez Salamanca, P., Fernández Fernández, R.F., Hornillos, V. y Lassaletta, J.M. (2022). Asymmetric Synthesis of Axially Chiral C N Atropisomers. Chemistry – A European Journal, 28 (28), e202104442. https://doi.org/10.1002/chem.202104442. | |
dc.identifier.issn | 1521-3765 | es |
dc.identifier.issn | 0947-6539 | es |
dc.identifier.uri | https://hdl.handle.net/11441/162138 | |
dc.description.abstract | Molecules with restricted rotation around a single
bond or atropisomers are found in a wide number of natural
products and bioactive molecules as well as in chiral ligands
for asymmetric catalysis and smart materials. Although most
of these compounds are biaryls and heterobiaryls displaying a
C C stereogenic axis, there is a growing interest in less
common and more challenging axially chiral C N atropisom-
ers. This review offers an overview of the various method-
ologies available for their asymmetric synthesis. A brief
introduction is initially given to contextualize these axially
chiral skeletons, including a historical background and
examples of natural products containing axially chiral C N
axes. The preparation of different families of C N based
atropisomers is then presented from anilides to chiral five-
and six-membered ring heterocycles. Special emphasis has
been given to modern catalytic asymmetric strategies over
the past decade for the synthesis of these chiral scaffolds.
Applications of these methods to the preparation of natural
products and biologically active molecules will be highlighted
along the text. | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación PID2019-106358GB-C21, PID2019-106358GB-C22, RYC-2017-22294, BES-2017-081561 | es |
dc.description.sponsorship | Junta de Andalucía P18-FR-3531, P18-FR-644, US-1262867, US-1260906 | es |
dc.format | application/pdf | es |
dc.format.extent | 44 p. | es |
dc.language.iso | eng | es |
dc.publisher | Wiley | es |
dc.relation.ispartof | Chemistry – A European Journal, 28 (28), e202104442. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Asymmetric Synthesis of Axially Chiral C N Atropisomers | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química orgánica | es |
dc.relation.projectID | PID2019-106358GB-C21 | es |
dc.relation.projectID | PID2019-106358GB-C22 | es |
dc.relation.projectID | RYC-2017-22294 | es |
dc.relation.projectID | BES-2017-081561 | es |
dc.relation.projectID | P18-FR-3531 | es |
dc.relation.projectID | P18-FR-644 | es |
dc.relation.projectID | US-1262867 | es |
dc.relation.projectID | US-1260906 | es |
dc.relation.publisherversion | https://doi.org/10.1002/chem.202104442 | es |
dc.identifier.doi | 10.1002/chem.202104442 | es |
dc.journaltitle | Chemistry – A European Journal | es |
dc.publication.volumen | 28 | es |
dc.publication.issue | 28 | es |
dc.publication.initialPage | e202104442 | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | es |
dc.contributor.funder | Junta de Andalucía | es |