dc.creator | Arias-Aragón, Francisco | es |
dc.creator | Tristán Clavijo, Enriqueta | es |
dc.creator | Martínez Gallego, Irene | es |
dc.creator | Robles Lanuza, Estefanía | es |
dc.creator | Coatl-Cuaya, Heriberto | es |
dc.creator | Martín-Cuevas, Celia | es |
dc.creator | Sánchez Hidalgo, Ana Carmen | es |
dc.creator | Rodríguez Moreno, Antonio | es |
dc.creator | Martínez Mir, Amalia | es |
dc.creator | Gómez Scholl, Francisco Manuel | es |
dc.date.accessioned | 2024-07-30T09:25:25Z | |
dc.date.available | 2024-07-30T09:25:25Z | |
dc.date.issued | 2023-05-13 | |
dc.identifier.citation | Arias-Aragón, F., Tristán Clavijo, E., Martínez Gallego, I., Robles Lanuza, E., Coatl-Cuaya, H., Martín-Cuevas, C.,...,Gómez Scholl, F.M. (2023). A Neuroligin-1 mutation associated with Alzheimer’s disease produces memory and age-dependent impairments in hippocampal plasticity. iScience, 26 (6), 106868. https://doi.org/10.1016/j.isci.2023.106868. | |
dc.identifier.issn | 2589-0042 | es |
dc.identifier.uri | https://hdl.handle.net/11441/161756 | |
dc.description.abstract | Alzheimer’s disease (AD) is characterized by memory impairments and age-dependent synapse loss. Experimental and clinical studies have shown decreased expression of the glutamatergic protein Neuroligin-1 (Nlgn1) in AD. However, the consequences of a sustained reduction of Nlgn1 are unknown. Here, we generated a knockin mouse that reproduces the NLGN1 Thr271fs mutation, identified in heterozygosis in a familial case of AD. We found that Nlgn1 Thr271fs mutation abolishes Nlgn1 expression in mouse brain. Importantly, heterozygous Nlgn1 Thr271fs mice showed delay-dependent amnesia for recognition memory. Electrophysiological recordings uncovered age-dependent impairments in basal synaptic transmission and long-term potentiation (LTP) in CA1 hippocampal neurons of heterozygous Nlgn1 Thr271fs mice. In contrast, homozygous Nlgn1 Thr271fs mice showed impaired fear-conditioning memory and normal basal synaptic transmission, suggesting unshared mechanisms for a partial or total loss of Nlgn1. These data suggest that decreased Nlgn1 may contribute to the synaptic and memory deficits in AD. | es |
dc.format | application/pdf | es |
dc.format.extent | 24 p. | es |
dc.language.iso | eng | es |
dc.publisher | Cell Press | es |
dc.relation.ispartof | iScience, 26 (6), 106868. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | A Neuroligin-1 mutation associated with Alzheimer’s disease produces memory and age-dependent impairments in hippocampal plasticity | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.relation.projectID | PID2019107677GBI00 | es |
dc.relation.projectID | FPU 17/04283 | es |
dc.relation.projectID | BES-2016-076579 | es |
dc.relation.projectID | P11- CVI-7599 | es |
dc.relation.projectID | P20_00881 | es |
dc.relation.projectID | RTI2018-101886-B- 100 | es |
dc.relation.projectID | PROYEXCEL_00573 | es |
dc.relation.publisherversion | https://www.cell.com/iscience/fulltext/S2589-0042(23)00945-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004223009458%3Fshowall%3Dtrue | es |
dc.identifier.doi | 10.1016/j.isci.2023.106868 | es |
dc.journaltitle | iScience | es |
dc.publication.volumen | 26 | es |
dc.publication.issue | 6 | es |
dc.publication.initialPage | 106868 | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |
dc.contributor.funder | Junta de Andalucía | es |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (MICINN). España | es |
dc.contributor.funder | Ministerio de Economia, Industria y Competitividad (MINECO). España | es |
dc.contributor.funder | Formación de Profesorado Universitario predoctoral fellowship del Ministerio de Universidades | es |