dc.creator | Lax, Carlos | es |
dc.creator | Mondo, Stephen J. | es |
dc.creator | Osorio Concepción, Macario | es |
dc.creator | Muszewska, Anna | es |
dc.creator | Corrochano Luque, María | es |
dc.creator | Gutiérrez Pozo, Gabriel | es |
dc.creator | Cánovas López, David | es |
dc.creator | Corrochano Peláez, Luis María | es |
dc.creator | Garre, Victoriano | es |
dc.date.accessioned | 2024-07-23T10:15:21Z | |
dc.date.available | 2024-07-23T10:15:21Z | |
dc.date.issued | 2024-07-18 | |
dc.identifier.citation | Lax, C., Mondo, S.J., Osorio Concepción, M., Muszewska, A., Corrochano Luque, M., Gutiérrez Pozo, G.,...,Garre, V. (2024). Symmetric and asymmetric DNA N6-adenine methylation regulates different biological responses in Mucorales. Nature Communications, 15 (1), 6066. https://doi.org/10.1038/s41467-024-50365-2. | |
dc.identifier.issn | 2041-1723 | es |
dc.identifier.uri | https://hdl.handle.net/11441/161632 | |
dc.description.abstract | DNA N6-adenine methylation (6mA) has recently gained importance as an epigenetic modification in eukaryotes. Its function in lineages with high levels, such as early-diverging fungi (EDF), is of particular interest. Here, we investigated the biological significance and evolutionary implications of 6mA in EDF, which exhibit divergent evolutionary patterns in 6mA usage. The analysis of two Mucorales species displaying extreme 6mA usage reveals that species with high 6mA levels show symmetric methylation enriched in highly expressed genes. In contrast, species with low 6mA levels show mostly asymmetric 6mA. Interestingly, transcriptomic regulation throughout development and in response to environmental cues is associated with changes in the 6mA landscape. Furthermore, we identify an EDF-specific methyltransferase, likely originated from endosymbiotic bacteria, as responsible for asymmetric methylation, while an MTA-70 methylation complex performs symmetric methylation. The distinct phenotypes observed in the corresponding mutants reinforced the critical role of both types of 6mA in EDF. | es |
dc.description.sponsorship | MCIN/AEI/ 10.13039/501100011033 y “FEDER Una manera de hacer Europa” de la Unión Europea - PID2021-124674NB-I00 y PID2021-128001OB-I00 | es |
dc.description.sponsorship | Fundación Séneca, Agencia de Ciencia y Tecnología de la Región de Murcia - 20897/PI/18 y 21969/PI/22 | es |
dc.description.sponsorship | Consejería de Transformación Económica, Industria, Conocimiento y Universidades de la Junta de Andalucía - P20-00622 | es |
dc.description.sponsorship | Office of Science of the US Department of Energy - DE-AC02-05CH11231 | es |
dc.format | application/pdf | es |
dc.format.extent | 21 p. | es |
dc.language.iso | eng | es |
dc.publisher | Nature Research | es |
dc.relation.ispartof | Nature Communications, 15 (1), 6066. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Symmetric and asymmetric DNA N6-adenine methylation regulates different biological responses in Mucorales | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Genética | es |
dc.relation.projectID | PID2021-124674NB-I00 | es |
dc.relation.projectID | PID2021-128001OB-I00 | es |
dc.relation.projectID | 20897/PI/18 | es |
dc.relation.projectID | 21969/PI/22 | es |
dc.relation.projectID | P20-00622 | es |
dc.relation.publisherversion | https://doi.org/10.1038/s41467-024-50365-2 | es |
dc.identifier.doi | 10.1038/s41467-024-50365-2 | es |
dc.journaltitle | Nature Communications | es |
dc.publication.volumen | 15 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 6066 | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | es |
dc.contributor.funder | Agencia Estatal de Investigación. España | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |
dc.contributor.funder | Comunidad Autónoma de Murcia. España | es |
dc.contributor.funder | Department of Energy Joint Genome Institute. U. S. | es |
dc.contributor.funder | Office of Science of the US Department of Energy. U. S. | es |