dc.creator | Cascajosa Lira, Antonio | es |
dc.creator | Prieto Ortega, Ana Isabel | es |
dc.creator | Pichardo Sánchez, Silvia | es |
dc.creator | Jos Gallego, Ángeles Mencía | es |
dc.creator | Cameán Fernández, Ana María | es |
dc.date.accessioned | 2024-07-16T12:13:25Z | |
dc.date.available | 2024-07-16T12:13:25Z | |
dc.date.issued | 2024-07-25 | |
dc.identifier.citation | Cascajosa Lira, A., Prieto Ortega, A.I., Pichardo Sánchez, S., Jos Gallego, Á.M. y Cameán Fernández, A.M. (2024). Protective effects of sulforaphane against toxic substances and contaminants: a systematic review. Phytomedicine, 130, 155731. https://doi.org/10.1016/j.phymed.2024.155731. | |
dc.identifier.issn | 0944-7113 | es |
dc.identifier.issn | 1618-095X | es |
dc.identifier.uri | https://hdl.handle.net/11441/161441 | |
dc.description.abstract | Background
Sulforaphane (SFN) is a dietary isothiocyanate, derived from glucoraphanin, present in cruciferous vegetables belonging to the Brassica genus. It is a biologically active phytochemical that acts as a nuclear factor erythroid 2-related factor 2 (Nrf2) inducer. Thus, it has been reported to have multiple protective functions including anticancer responses and protection against a toxic agent's action.
Purpose
The present work systematically reviewed and synthesised the protective properties of sulforaphane against a toxic agent. This review reveals the mechanism of the action of SFN in each organ or system.
Methods
The PRISMA guideline was followed in this sequence: researched literature, organised retrieved documents, abstracted relevant information, assessed study quality and bias, synthesised data, and prepared a comprehensive report. Searches were conducted on Science Direct and PubMed using the keywords "Sulforaphane" AND (“protective effects” OR “protection against”).
Results
Reports showed that liver and the nervous system are the target organs on which attention was focused, and this might be due to the key role of oxidative stress in liver and neurodegenerative diseases. However, protective activities have also been demonstrated in the lungs, heart, immune system, kidneys, and endocrine system. SFN exerts its protective effects by activating the Nrf2 pathway, which enhances antioxidant defenses and reduces oxidative stress. It also suppresses inflammation by decreasing interleukin production. Moreover, SFN inhibits apoptosis by preventing caspase 3 cleavage and increasing Bcl2 levels. Overall, SFN demonstrates multifaceted mechanisms to counteract the adverse effects of toxic agents.
Conclusion
SFN has potential clinical applications as a chemoprotective agent. Nevertheless, more studies are necessary to set the safe doses of SFN in humans. | es |
dc.description.sponsorship | Consejería de Economía y Conocimiento de la Junta de Andalucía, España - P18-TP-2147 | es |
dc.format | application/pdf | es |
dc.format.extent | 26 p. | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Phytomedicine, 130, 155731. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Sulforaphane | es |
dc.subject | Toxicity | es |
dc.subject | Protective | es |
dc.subject | Anti-inflammatory | es |
dc.subject | Antioxidant | es |
dc.title | Protective effects of sulforaphane against toxic substances and contaminants: a systematic review | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal | es |
dc.relation.projectID | P18-TP-2147 | es |
dc.relation.publisherversion | https://doi.org/10.1016/j.phymed.2024.155731 | es |
dc.identifier.doi | 10.1016/j.phymed.2024.155731 | es |
dc.journaltitle | Phytomedicine | es |
dc.publication.volumen | 130 | es |
dc.publication.initialPage | 155731 | es |
dc.contributor.funder | Junta de Andalucía | es |