Artículo
Protein sorting upon exit from the endoplasmic reticulum dominates Golgi biogenesis in budding yeast
Autor/es | Sasaki, Saku
Schlarmann, Philipp Hanaoka, Kazuki Nishii, Hinako Moriya, Hisao Muñiz Guinea, Manuel Funato, Kouichi |
Departamento | Universidad de Sevilla. Departamento de Biología Celular |
Fecha de publicación | 2023-02-24 |
Fecha de depósito | 2024-07-03 |
Publicado en |
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Resumen | Cells sense and control the number and quality of their organelles, but the underlying mechanisms of this regulation are not understood. Our recent research in the yeast Saccharomyces cerevisiae has shown that long acyl ... Cells sense and control the number and quality of their organelles, but the underlying mechanisms of this regulation are not understood. Our recent research in the yeast Saccharomyces cerevisiae has shown that long acyl chain ceramides in the endoplasmic reticulum (ER) membrane and the lipid moiety of glycosylphosphatidylinositol (GPI) anchor determine the sorting of GPI-anchored proteins in the ER. Here, we show that a mutant strain, which produces shorter ceramides than the wild-type strain, displays a different count of Golgi cisternae. Moreover, deletions of proteins that remodel the lipid portion of GPI anchors resulted in an abnormal number of Golgi cisternae. Thus, our study reveals that protein sorting in the ER plays a critical role in maintaining Golgi biogenesis. |
Agencias financiadoras | Japan Society for the Promotion of Science (JSPS). Japan Agencia Estatal de Investigación. España Junta de Andalucía European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) |
Identificador del proyecto | JSPS 19H02922
PID2020-119505GB-I00 PY20_01240 US-1380893 |
Cita | Sasaki, S., Schlarmann, P., Hanaoka, K., Nishii, H., Moriya, H., Muñiz Guinea, M. y Funato, K. (2023). Protein sorting upon exit from the endoplasmic reticulum dominates Golgi biogenesis in budding yeast. FEBS Letters, 598 (5), 548-555. https://doi.org/10.1002/1873-3468.14830. |
Ficheros | Tamaño | Formato | Ver | Descripción |
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FEBS Letters - 2024 - Sasaki.pdf | 1.382Mb | [PDF] | Ver/ | |