dc.creator | Sasaki, Saku | es |
dc.creator | Schlarmann, Philipp | es |
dc.creator | Hanaoka, Kazuki | es |
dc.creator | Nishii, Hinako | es |
dc.creator | Moriya, Hisao | es |
dc.creator | Muñiz Guinea, Manuel | es |
dc.creator | Funato, Kouichi | es |
dc.date.accessioned | 2024-07-03T11:39:42Z | |
dc.date.available | 2024-07-03T11:39:42Z | |
dc.date.issued | 2023-02-24 | |
dc.identifier.citation | Sasaki, S., Schlarmann, P., Hanaoka, K., Nishii, H., Moriya, H., Muñiz Guinea, M. y Funato, K. (2023). Protein sorting upon exit from the endoplasmic reticulum dominates Golgi biogenesis in budding yeast. FEBS Letters, 598 (5), 548-555. https://doi.org/10.1002/1873-3468.14830. | |
dc.identifier.issn | 0014-5793 | es |
dc.identifier.issn | 1873-3468 | es |
dc.identifier.uri | https://hdl.handle.net/11441/161059 | |
dc.description.abstract | Cells sense and control the number and quality of their organelles, but the underlying mechanisms of this regulation are not understood. Our recent research in the yeast Saccharomyces cerevisiae has shown that long acyl chain ceramides in the endoplasmic reticulum (ER) membrane and the lipid moiety of glycosylphosphatidylinositol (GPI) anchor determine the sorting of GPI-anchored proteins in the ER. Here, we show that a mutant strain, which produces shorter ceramides than the wild-type strain, displays a different count of Golgi cisternae. Moreover, deletions of proteins that remodel the lipid portion of GPI anchors resulted in an abnormal number of Golgi cisternae. Thus, our study reveals that protein sorting in the ER plays a critical role in maintaining Golgi biogenesis. | es |
dc.description.sponsorship | Japan Society for the Promotion of Science (JSPS) - 19H02922 | es |
dc.description.sponsorship | AEI/10.13039/501100011033 - PID2020-119505GB-I00 | es |
dc.description.sponsorship | Junta de Andalucía y fondos europeos FEDER - PY20_01240 y US-1380893 | es |
dc.format | application/pdf | es |
dc.format.extent | 8 p. | es |
dc.language.iso | eng | es |
dc.publisher | Willey | es |
dc.relation.ispartof | FEBS Letters, 598 (5), 548-555. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | ceramide | es |
dc.subject | endoplasmic reticulum | es |
dc.subject | Golgi biogenesis | es |
dc.subject | GPI | es |
dc.subject | lipid remodeling | es |
dc.subject | protein sorting | es |
dc.title | Protein sorting upon exit from the endoplasmic reticulum dominates Golgi biogenesis in budding yeast | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Biología Celular | es |
dc.relation.projectID | JSPS 19H02922 | es |
dc.relation.projectID | PID2020-119505GB-I00 | es |
dc.relation.projectID | PY20_01240 | es |
dc.relation.projectID | US-1380893 | es |
dc.relation.publisherversion | https://doi.org/10.1002/1873-3468.14830 | es |
dc.identifier.doi | 10.1002/1873-3468.14830 | es |
dc.journaltitle | FEBS Letters | es |
dc.publication.volumen | 598 | es |
dc.publication.issue | 5 | es |
dc.publication.initialPage | 548 | es |
dc.publication.endPage | 555 | es |
dc.contributor.funder | Japan Society for the Promotion of Science (JSPS). Japan | es |
dc.contributor.funder | Agencia Estatal de Investigación. España | es |
dc.contributor.funder | Junta de Andalucía | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |