dc.creator | Carrillo Carrión, Carolina | es |
dc.creator | Comaills, Valentine | es |
dc.creator | Visiga, Ana M. | es |
dc.creator | Gauthier, Benoit R. | es |
dc.creator | Khiar, Noureddine | es |
dc.date.accessioned | 2024-06-13T13:47:01Z | |
dc.date.available | 2024-06-13T13:47:01Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Carrillo Carrión, C., Comaills, V., Visiga, A.M., Gauthier, B.R. y Khiar, N. (2023). Enzyme-Responsive Zr-Based Metal-Organic Frameworks for Controlled Drug Delivery: Taking Advantage of Clickable PEG-Phosphate Ligands. ACS Applied Materials and Interfaces, 15 (23), 27600-27611. https://doi.org/10.1021/acsami.3c03230. | |
dc.identifier.issn | 1944-8244 | es |
dc.identifier.issn | 1944-8252 | es |
dc.identifier.uri | https://hdl.handle.net/11441/160464 | |
dc.description.abstract | We report for the first time the controlled drug release from a nanoscale Zr-based metal-organic framework (MOF), UiO-66, in the presence of the enzyme alkaline phosphatase (ALP). This unprecedented reactivity was possible thanks to the prior functionalization of the MOF with N3-PEG-PO3 ligands, which were designed for three specific aims: (1) to impart colloidal stability in phosphate-containing media; (2) to endow the MOF with multifunctionality thanks to azide groups for the covalent attachment of an imaging agent by click-chemistry; and (3) to confer stimuli-responsive properties, specifically the selective release of doxorubicin triggered by the enzymatic activity of ALP. Cell studies revealed that the functionalization of the MOF with N3-(PEG)20-PO3 ligands improved their intracellular stability and led to a sustained drug release compared to the bare MOF. More importantly, an enhanced drug release was observed in cells with higher expression of ALP genes (HeLa versus MDA-MB-231 and MCF7), confirming the ALP-responsiveness of the system inside living cells. | es |
dc.description.sponsorship | Ministerio de Ciencia, Innovación y Universidades RYC-2019-027527-I, PID2020-119949RB-I00 | es |
dc.description.sponsorship | European Commission PY20_00882, CV20-04221 | es |
dc.description.sponsorship | Junta de Andalucía FQM-313 | es |
dc.description.sponsorship | Asociación Española Contra el Cáncer INVES20033COMA | es |
dc.description.sponsorship | Marie Sklodowska-Curie Individual Fellowship 101026137 | es |
dc.description.sponsorship | European Cooperation in Science and Technology CA-18132 | es |
dc.format | application/pdf | es |
dc.format.extent | 12 p. | es |
dc.language.iso | eng | es |
dc.publisher | American Chemical Society | es |
dc.relation.ispartof | ACS Applied Materials and Interfaces, 15 (23), 27600-27611. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Biocompatibility | es |
dc.subject | Click chemistry | es |
dc.subject | Controlled drug-release | es |
dc.subject | Enzyme-responsive | es |
dc.subject | Metal−organic frameworks | es |
dc.title | Enzyme-Responsive Zr-Based Metal-Organic Frameworks for Controlled Drug Delivery: Taking Advantage of Clickable PEG-Phosphate Ligands | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Biología Celular | es |
dc.relation.projectID | RYC-2019-027527-I | es |
dc.relation.projectID | PID2020-119949RB-I00 | es |
dc.relation.projectID | PY20_00882 | es |
dc.relation.projectID | CV20-04221 | es |
dc.relation.projectID | FQM-313 | es |
dc.relation.projectID | INVES20033COMA | es |
dc.relation.projectID | 101026137 | es |
dc.relation.projectID | CA-18132 | es |
dc.relation.publisherversion | https://doi.org/10.1021/acsami.3c03230 | es |
dc.identifier.doi | 10.1021/acsami.3c03230 | es |
dc.journaltitle | ACS Applied Materials and Interfaces | es |
dc.publication.volumen | 15 | es |
dc.publication.issue | 23 | es |
dc.publication.initialPage | 27600 | es |
dc.publication.endPage | 27611 | es |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (MICINN). España | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |
dc.contributor.funder | Junta de Andalucía | es |
dc.contributor.funder | Asociación Española Contra el Cáncer | es |
dc.contributor.funder | Marie Sklodowska-Curie Individual Fellowship | es |
dc.contributor.funder | European Cooperation in Science and Technology (COST) | es |