dc.creator | Grilo Bensusan, Israel | es |
dc.creator | Pascasio, Juan Manuel | es |
dc.creator | Tirado, Juan Luis | es |
dc.creator | López Pardo, Francisco Jesús | es |
dc.creator | Ortega Ruiz, Francisco | es |
dc.creator | Sousa, José Manuel | es |
dc.creator | Rodríguez Puras, María José | es |
dc.creator | Ferrer, María Teresa | es |
dc.creator | Gómez Bravo, Miguel Ángel | es |
dc.creator | Grilo Reina, Antonio | es |
dc.date.accessioned | 2024-05-22T13:46:04Z | |
dc.date.available | 2024-05-22T13:46:04Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Grilo Bensusan, I., Pascasio, J.M., Tirado, J.L., López Pardo, F.J., Ortega Ruiz, F., Sousa, J.M.,...,Grilo Reina, A. (2017). The utility of the macro-aggregated albumin lung perfusion scan in the diagnosis and prognosis of hepatopulmonary syndrome in cirrhotic patients candidates for liver transplantation. Revista Española de Enfermedades Digestivas, 109 (5), 335-343. https://doi.org/10.17235/reed.2017.4219/2016. | |
dc.identifier.issn | 1130-0108 | es |
dc.identifier.issn | 2340-4167 | es |
dc.identifier.uri | https://hdl.handle.net/11441/158821 | |
dc.description.abstract | Background: The macro-aggregated albumin lung perfusion
scan (99mTc-MAA) is a diagnostic method for hepatopulmonary syn
drome (HPS).
Aim: To determine the sensitivity of 99mTc-MAA in diagnosing
HPS, to establish the utility of 99mTc-MAA in determining the influ
ence of HPS on hypoxemia in patients with concomitant pulmonary
disease and to determine the correlation between 99mTc-MAA values
and other respiratory parameters.
Methods: Data from 115 cirrhotic patients who were eligi
ble for liver transplantation (LT) were prospectively analyzed. A
transthoracic contrast echocardiography and 99mTc-MAA were per
formed in 85 patients, and 74 patients were diagnosed with HPS.
Results: The overall sensitivity of 99mTc-MAA for the diagnosis
of HPS was 18.9% (14/74) in all of the HPS cases and 66.7%
(4/6) in the severe to very severe cases. In HPS patients who did
not have lung disease, the degree of brain uptake of 99mTc-MAA
was correlated with the alveolar-arterial oxygen gradient (A-a PO2
)
(r = 0.32, p < 0.05) and estimated oxygen shunt (r = 0.41, p <
0.05) and inversely correlated with partial pressure of arterial oxy
gen (PaO2
) while breathing 100% O2
(r = -0.43, p < 0.05). The
99mTc-MAA was positive in 20.6% (7/36) of the patients with HPS
and lung disease. The brain uptake of 99mTc-MAA was not associ
ated with mortality and normalized in all cases six months after LT.
Conclusions: The 99mTc-MAA is a low sensitivity test for the
diagnosis of HPS that can be useful in patients who have concomi
tant lung disease and in severe to very severe cases of HPS. It was
not related to mortality, and brain uptake normalized after LT. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 p. | es |
dc.language.iso | eng | es |
dc.publisher | Aran Ediciones S.A. | es |
dc.relation.ispartof | Revista Española de Enfermedades Digestivas, 109 (5), 335-343. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Cirrhosis | es |
dc.subject | Ascites | es |
dc.subject | Contrast echocardiography | es |
dc.subject | Pulmonary vascular diseases | es |
dc.subject | Perioperative care | es |
dc.title | The utility of the macro-aggregated albumin lung perfusion scan in the diagnosis and prognosis of hepatopulmonary syndrome in cirrhotic patients candidates for liver transplantation | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Cirugía | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.contributor.affiliation | Instituto de Biomedicina de Sevilla (IBIS) | es |
dc.relation.publisherversion | https://www.reed.es/ArticuloFicha.aspx?id=1085&hst=0&idR=48&tp=1 | es |
dc.identifier.doi | 10.17235/reed.2017.4219/2016 | es |
dc.journaltitle | Revista Española de Enfermedades Digestivas | es |
dc.publication.volumen | 109 | es |
dc.publication.issue | 5 | es |
dc.publication.initialPage | 335 | es |
dc.publication.endPage | 343 | es |