Article
Concomitant administration of seasonal influenza and COVID-19 mRNA vaccines
Author/s | Aydillo, Teresa
Balsera-Manzanero, Maria Rojo-Fernandez, Amaya Escalera, Alba Salamanca Rivera, Celia Pachón Díaz, Jerónimo Muñoz-García, María Del Mar Sánchez-Cordero, María José Sanchez Cespedes, Javier García-Sastre, Adolfo Cordero Matia, María Elisa |
Department | Universidad de Sevilla. Departamento de Medicina Universidad de Sevilla. Departamento de Medicina Preventiva y Salud Pública |
Publication Date | 2023 |
Deposit Date | 2024-05-20 |
Awards | Premio Mensual Publicación Científica Destacada de la US. Facultad de Medicina |
Abstract | Current clinical guidelines support the concomitant administration of seasonal influenza vaccines and COVID-19 mRNA boosters vaccine. Whether dual vaccination may impact vaccine immunogenicity due to an interference between ... Current clinical guidelines support the concomitant administration of seasonal influenza vaccines and COVID-19 mRNA boosters vaccine. Whether dual vaccination may impact vaccine immunogenicity due to an interference between influenza or SARS-CoV-2 antigens is unknown. We aimed to understand the impact of mRNA COVID-19 vaccines administered concomitantly on the immune response to influenza vaccines. For this, 128 volunteers were vaccinated during the 22-23 influenza season. Three groups of vaccination were assembled: FLU vaccine only (46, 35%) versus volunteers that received the mRNA bivalent COVID-19 vaccines concomitantly to seasonal influenza vaccines, FluCOVID vaccine in the same arm (42, 33%) or different arm (40, 31%), respectively. Sera and whole blood were obtained the day of vaccination, +7, and +28 days after for antibody and T cells response quantification. As expected, side effects were increased in individuals who received the FluCOVID vaccine as compared to FLU vaccine only based on the known reactogenicity of mRNA vaccines. In general, antibody levels were high at 4 weeks post-vaccination and differences were found only for the H3N2 virus when administered in different arms compared to the other groups at day 28 post-vaccination. Additionally, our data showed that subjects that received the FluCOVID vaccine in different arm tended to have better antibody induction than those receiving FLU vaccines for H3N2 virus in the absence of pre-existing immunity. Furthermore, no notable differences in the influenza-specific cellular immune response were found for any of the vaccination groups. Our data supports the concomitant administration of seasonal influenza and mRNA COVID-19 vaccines. |
Funding agencies | Consejeria de Economia, Conocimiento, Empresas y Universidad, Secretaria General de Universidades, Investigacion y Tecnologia, Junta de Andalucia, Spain Instituto de Salud Carlos III Ministerio de Ciencia e Innovacion and Union Europea - NextGeneration EU SEM-CIVIC National Institute of Allergy and Infectious Diseases American Lung Association CEIRR-CRIPT Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas CIBERINFEC |
Project ID. | P18-RT-3320
CB21/13/00006 75N93019C00051 1034091 75N93021C00014 |
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