dc.creator | Guerrero, Fátima | es |
dc.creator | Carmona, Andrés | es |
dc.creator | Vidal, Victoria | es |
dc.creator | Franco, Ana | es |
dc.creator | Martín-Malo, Alejandro | es |
dc.creator | Carrillo-Carrión, Carolina | es |
dc.creator | Sánchez Fernández, Elena Matilde | es |
dc.date.accessioned | 2024-05-14T08:22:21Z | |
dc.date.available | 2024-05-14T08:22:21Z | |
dc.date.issued | 2023-10-05 | |
dc.identifier.citation | Guerrero, F., Carmona, A., Vidal, V., Franco, A., Martín-Malo, A., Carrillo-Carrión, C. y Sánchez Fernández, E.M. (2023). A selenoureido-iminoglycolipid transported by zeolitic-imidazolate framework nanoparticles: a novel antioxidant therapeutic approach. Nanoscale Horizons, 8 (12), 1700-1710. https://doi.org/10.1039/D3NH00363A. | |
dc.identifier.issn | 2055-6764 | es |
dc.identifier.issn | 2055-6756 | es |
dc.identifier.uri | https://hdl.handle.net/11441/158257 | |
dc.description.abstract | A selenium-containing metal–organic framework with remarkable
antioxidant capacity and ROS-scavenging activity was constructed by a
controlled de novo encapsulation approach of a glycoconjugate
mimetic, specifically a sp2
-iminoglycolipid bearing a selenoureido
fragment (DSeU), within a zeolitic-imidazolate framework exoskeleton.
Biocompatible and homogeneous nanosized particles of B70 nm
(DSeU@ZIF8) were obtained, which could be efficiently internalized
in cells, overcoming the poor solubility in biological media and limited
bioavailability of glycolipids. The ZIF-particle served as nanocarrier for
the intracellular delivery of the selenocompound to cells, promoted by
the acidic pH inside endosomes/lysosomes. As demonstrated by
in vitro studies, the designed DSeU@ZIF8 nanoparticles displayed a
high antioxidant activity at low doses; lower intracellular ROS levels
were observed upon the uptake of DSeU@ZIF8 by human endothelial
cells. Even more interesting was the finding that these DSeU@ZIF8
particles were able to reverse to a certain level the oxidative stress
induced in cells by pre-treatment with an oxidizing agent. This possibility of modulating the oxidative stress in living cells may have
important implications in the treatment of diverse pathological complications that are generally accompanied with elevated ROS levels. | es |
dc.description.sponsorship | Ministerio de Ciencia, Innovación y Universidades de España y Agencia Española de Investigación RYC-2019-027527-I - PID2022-141034OBC22 - PID2019-105858RB-I00 - PID2022-141034OBC21 | es |
dc.description.sponsorship | Junta de Andalucía CSyF 2022 - PI-0130-2022 | es |
dc.format | application/pdf | es |
dc.format.extent | 11 | es |
dc.language.iso | eng | es |
dc.publisher | Royal Society of Chemistry | es |
dc.relation.ispartof | Nanoscale Horizons, 8 (12), 1700-1710. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | A selenoureido-iminoglycolipid transported by zeolitic-imidazolate framework nanoparticles: a novel antioxidant therapeutic approach | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química orgánica | es |
dc.relation.projectID | RYC-2019-027527-I - PID2022-141034OBC22 - PID2019-105858RB-I00 - PID2022-141034OBC21 | es |
dc.relation.projectID | PI-0130-2022 | es |
dc.relation.publisherversion | DOI https://doi.org/10.1039/D3NH00363A | es |
dc.identifier.doi | 10.1039/D3NH00363A | es |
dc.journaltitle | Nanoscale Horizons | es |
dc.publication.volumen | 8 | es |
dc.publication.issue | 12 | es |
dc.publication.initialPage | 1700 | es |
dc.publication.endPage | 1710 | es |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades de España y Agencia Española de Investigación | es |
dc.contributor.funder | Junta de Andalucía | es |