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dc.creatorRamos, Fernandoes
dc.creatorHermosín, María Lourdeses
dc.creatorFuertes-Núñez, Martaes
dc.creatorMartínez, Pilares
dc.creatorRodriguez-Medina, Carloses
dc.creatorBarrios, Manueles
dc.creatorIbáñez, Franciscoes
dc.creatorBernal, Teresaes
dc.creatorOlave, Maria Teresaes
dc.creatorÁlvarez, Miguel Ángeles
dc.creatorCaballero Velázquez, Teresaes
dc.creatorSerrano, Josefinaes
dc.date.accessioned2024-04-12T12:55:32Z
dc.date.available2024-04-12T12:55:32Z
dc.date.issued2023-11-28
dc.identifier.citationRamos, F., Hermosín, M.L., Fuertes-Núñez, M., Martínez, P., Rodriguez-Medina, C., Barrios, M.,...,Serrano, J. (2023). Survival Outcomes and Health-Related Quality of Life in Older Adults Diagnosed with Acute Myeloid Leukemia Receiving Frontline Therapy in Daily Practice. Journal of personalized medicine, 13 (12), 1667. https://doi.org/10.3390/jpm13121667.
dc.identifier.issn2075-4426es
dc.identifier.urihttps://hdl.handle.net/11441/156838
dc.description.abstractAcute myeloid leukemia has a poor prognosis in older adults, and its management is often unclear due to its underrepresentation in clinical trials. Both overall survival (OS) and healthrelated quality-of-life (HRQoL) are key outcomes in this population, and patient-reported outcomes may contribute to patient stratification and treatment assignment. This prospective study included 138 consecutive patients treated in daily practice with the currently available non-targeted therapies (intensive chemotherapy [IC], attenuated chemotherapy [AC], hypomethylating agents [HMA], or palliative care [PC]). We evaluated patients’ condition at diagnosis (Life expectancy [Lee Index for Older Adults], Geriatric Assessment in Hematology [GAH scale], HRQoL [EQ-5D-5L questionnaire], and fatigue [fatigue items of the QLQ-C30 scale]), OS, early death (ED), treatment tolerability (TT) and change in HRQoL over 12 months follow-up. The median OS was 7.1 months (IC not reached, AC 5.9, HMA 8.8, and PC 1.0). Poor risk AML category and receiving just palliative care, as well as a higher Lee index score in the patients receiving active therapy, independently predicted a shorter OS. The Lee Index and GAH scale were not useful for predicting TT. The white blood cell count was a valid predictor for ED. Patients’ HRQoL remained stable during follow-up.es
dc.formatapplication/pdfes
dc.format.extent16 p.es
dc.language.isoenges
dc.publisherMPDIes
dc.relation.ispartofJournal of personalized medicine, 13 (12), 1667.
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAcute myeloid leukemiaes
dc.subjectElderlyes
dc.subjectSurvivales
dc.subjectEarly deathes
dc.subjectHealth-related quality of lifees
dc.subjectLife expectancyes
dc.subjectGeriatric assessmentes
dc.subjectFatiguees
dc.titleSurvival Outcomes and Health-Related Quality of Life in Older Adults Diagnosed with Acute Myeloid Leukemia Receiving Frontline Therapy in Daily Practicees
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationInstituto de Biomedicina de Sevilla (IBIS)es
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Medicinaes
dc.relation.publisherversionhttps://www.mdpi.com/2075-4426/13/12/1667es
dc.identifier.doi10.3390/jpm13121667es
dc.journaltitleJournal of personalized medicinees
dc.publication.volumen13es
dc.publication.issue12es
dc.publication.initialPage1667es

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