dc.creator | Morales-Camacho, R.M. | es |
dc.creator | Caballero Velázquez, Teresa | es |
dc.creator | Borrero, J.J. | es |
dc.creator | Bernal, R. | es |
dc.creator | Prats-Martín, C. | es |
dc.date.accessioned | 2024-04-11T13:48:30Z | |
dc.date.available | 2024-04-11T13:48:30Z | |
dc.date.issued | 2024-01-12 | |
dc.identifier.citation | Morales-Camacho, R.M., Caballero Velázquez, T., Borrero, J.J., Bernal, R. y Prats-Martín, C. (2024). Hematological Neoplasms with Eosinophilia. Cancers, 16 (2), 337. https://doi.org/10.3390/cancers16020337. | |
dc.identifier.issn | 2072-6694 | es |
dc.identifier.uri | https://hdl.handle.net/11441/156816 | |
dc.description.abstract | The diagnostic assessment of eosinophilias is complex, requiring a multidisciplinary approach and often involving diagnostic challenges. This work aims for a better understanding of the cytomorphological features, immunophenotype, and biological activity of the eosinophil.
Additionally, the concepts of peripheral and bone marrow eosinophilia and their potential causes
are reviewed. Finally, the review focuses on the broad differential diagnosis of hematologic diseases
that may underlie eosinophilia and how to diagnose them. Among the findings that should raise
suspicion of hematologic diseases associated with eosinophilia are the presence of splenomegaly
and/or lymphadenopathy or an abnormal blood count. In recent years, with advances in molecular
techniques, new hematologic malignancies such as myeloid/lymphoid neoplasms with eosinophilia
and tyrosine kinase gene fusions are being defined, where eosinophilia can serve as a guiding sign.
In these cases, an accurate diagnosis allows for the use of targeted therapy with an improvement in
the quality of life and survival of patients. | es |
dc.description.abstract | Eosinophils in peripheral blood account for 0.3–5% of leukocytes, which is equivalent to
0.05–0.5 × 109/L. A count above 0.5 × 109/L is considered to indicate eosinophilia, while a count
equal to or above 1.5 × 109/L is defined as hypereosinophilia. In bone marrow aspirate, eosinophilia
is considered when eosinophils make up more than 6% of the total nuclear cells. In daily clinical
practice, the most common causes of reactive eosinophilia are non-hematologic, whether they are
non-neoplastic (allergic diseases, drugs, infections, or immunological diseases) or neoplastic (solid tumors). Eosinophilia that is associated with a hematological malignancy may be reactive or secondary
to the production of eosinophilopoietic cytokines, and this is mainly seen in lymphoid neoplasms
(Hodgkin lymphoma, mature T-cell neoplasms, lymphocytic variant of hypereosinophilic syndrome,
and B-acute lymphoblastic leukemia/lymphoma). Eosinophilia that is associated with a hematological malignancy may also be neoplastic or primary, derived from the malignant clone, usually in
myeloid neoplasms or with its origin in stem cells (myeloid/lymphoid neoplasms with eosinophilia
and tyrosine kinase gene fusions, acute myeloid leukemia with core binding factor translocations,
mastocytosis, myeloproliferative neoplasms, myelodysplastic/myeloproliferative neoplasms, and
myelodysplastic neoplasms). There are no concrete data in standardized cytological and cytometric
procedures that could predict whether eosinophilia is reactive or clonal. The verification is usually
indirect, based on the categorization of the accompanying hematologic malignancy. This review
focuses on the broad differential diagnosis of hematological malignancies with eosinophilia. | es |
dc.format | application/pdf | es |
dc.format.extent | 28 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Cancers, 16 (2), 337. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Eosinophilia | es |
dc.subject | Hematological neoplasm | es |
dc.subject | Myeloid/lymphoid neoplasm with eosinophilia | es |
dc.subject | Tyrosine kinase gene fusions | es |
dc.subject | Acute leukemia | es |
dc.title | Hematological Neoplasms with Eosinophilia | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Instituto de Biomedicina de Sevilla (IBIS) | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://www.mdpi.com/2072-6694/16/2/337 | es |
dc.identifier.doi | 10.3390/cancers16020337 | es |
dc.journaltitle | Cancers | es |
dc.publication.volumen | 16 | es |
dc.publication.issue | 2 | es |
dc.publication.initialPage | 337 | es |