dc.creator | Espinosa Oliva, Ana María | es |
dc.creator | Ruiz Laza, Rocío | es |
dc.creator | Sarmiento Soto, Manuel | es |
dc.creator | Boza Serrano, Antonio | es |
dc.creator | Rodríguez Pérez, Ana I | es |
dc.creator | Roca Ceballos, María Angustias | es |
dc.creator | García Revilla, Juan | es |
dc.creator | Santiago Pavón, Martiniano | es |
dc.creator | Carvajal Vázquez, Ana Eloísa | es |
dc.creator | Vázquez Carretero, María Dolores | es |
dc.creator | García Miranda, Pablo | es |
dc.creator | Oliva Martin, María José | es |
dc.creator | Machado Quintana, Alberto | es |
dc.creator | Peral Rubio, María José | es |
dc.creator | Herrera Carmona, Antonio José | es |
dc.creator | Venero Recio, José Luis | es |
dc.creator | Martínez de Pablos, Rocío | es |
dc.creator | neuroinflammation | es |
dc.date.accessioned | 2024-04-11T09:41:23Z | |
dc.date.available | 2024-04-11T09:41:23Z | |
dc.date.issued | 2024-01-16 | |
dc.identifier.citation | Espinosa Oliva, A.M., Ruiz Laza, R., Sarmiento Soto, M., Boza Serrano, A., Rodríguez Pérez, A.I., Roca Ceballos, M.A.,...,neuroinflammation, (2024). Inflammatory bowel disease induces pathologicalα-synucleinaggregation in the human gut and brain. Neuropathology and Applied Neurobiology, 50 (1), e12962. https://doi.org/10.1111/nan.12962. | |
dc.identifier.issn | 0305-1846 / 1365-2990 | es |
dc.identifier.uri | https://hdl.handle.net/11441/156788 | |
dc.description.abstract | Aims
According to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous system (ENS) and spreads to the brain through the vagus nerve. In this work, we studied whether inflammatory bowel diseases (IBDs) in humans can progress with the emergence of pathogenic α-synuclein (α-syn) in the gastrointestinal tract and midbrain dopaminergic neurons.
Methods
We have analysed the gut and the ventral midbrain from subjects previously diagnosed with IBD and form a DSS-based rat model of gut inflammation in terms of α-syn pathology.
Results
Our data support the existence of pathogenic α-syn in both the gut and the brain, thus reinforcing the potential role of the ENS as a contributing factor in PD aetiology. Additionally, we have analysed the effect of a DSS-based rat model of gut inflammation to demonstrate (i) the appearance of P-α-syn inclusions in both Auerbach's and Meissner's plexuses (gut), (ii) an increase in α-syn expression in the ventral mesencephalon (brain) and (iii) the degeneration of nigral dopaminergic neurons, which all are considered classical hallmarks in PD.
Conclusion
These results strongly support the plausibility of Braak's hypothesis and emphasise the significance of peripheral inflammation and the gut-brain axis in initiating α-syn aggregation and transport to the substantia nigra, resulting in neurodegeneration. | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad de España SAF2015-64171-R | es |
dc.description.sponsorship | Ministerio de Ciencia, Innovación y Universidades de España RTI2018-098830-B-I00 | es |
dc.description.sponsorship | Ministerio de Salud español PI17/00828 | es |
dc.description.sponsorship | Junta de Andalucía CTS 5884 | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Wiley | es |
dc.relation.ispartof | Neuropathology and Applied Neurobiology, 50 (1), e12962. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | alpha-synuclein | es |
dc.subject | inflammatory bowel disease | es |
dc.subject | neurodegeneration | es |
dc.subject | Parkinson’sdisease | es |
dc.title | Inflammatory bowel disease induces pathologicalα-synucleinaggregation in the human gut and brain | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular | es |
dc.relation.projectID | SAF2015-64171-R | es |
dc.relation.projectID | RTI2018-098830-B-I00 | es |
dc.relation.projectID | PI17/00828 | es |
dc.relation.projectID | CTS 5884 | es |
dc.relation.publisherversion | https://doi.org/10.1111/nan.12962 | es |
dc.identifier.doi | 10.1111/nan.12962 | es |
dc.journaltitle | Neuropathology and Applied Neurobiology | es |
dc.publication.volumen | 50 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | e12962 | es |
dc.contributor.funder | Ministerio de Economía y Competitividad (MINECO). España | es |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (MICINN). España | es |
dc.contributor.funder | Ministerio de Sanidad. España | es |
dc.contributor.funder | Junta de Andalucía | es |