Artículo
A genetic profling guideline to support diagnosis and clinical management of lymphomas
Autor/es | Sánchez Beato, Margarita
Méndez, Miriam Criado Guirado, María José Pedrosa, Lucía Sequero, Silvia Yanguas-Casás, Natalia Cruz Merino, Luis de la Gálvez, Laura Llanos, Marta García, Juan Fernando Provencio, Mariano |
Departamento | Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2023 |
Fecha de depósito | 2024-02-29 |
Publicado en |
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Resumen | The new lymphoma classifcations (International Consensus Classifcation of Mature Lymphoid Neoplasms, and 5th World
Health Organization Classifcation of Lymphoid Neoplasms) include genetics as an integral part of lymphoma ... The new lymphoma classifcations (International Consensus Classifcation of Mature Lymphoid Neoplasms, and 5th World Health Organization Classifcation of Lymphoid Neoplasms) include genetics as an integral part of lymphoma diagnosis, allowing better lymphoma subclassifcation, patient risk stratifcation, and prediction of treatment response. Lymphomas are characterized by very few recurrent and disease-specifc mutations, and most entities have a heterogenous genetic landscape with a long tail of recurrently mutated genes. Most of these occur at low frequencies, refecting the clinical heterogeneity of lymphomas. Multiple studies have identifed genetic markers that improve diagnostics and prognostication, and next generation sequencing is becoming an essential tool in the clinical laboratory. This review provides a “next-generation sequencing” guide for lymphomas. It discusses the genetic alterations of the most frequent mature lymphoma entities with diagnostic, prognostic, and predictive potential and proposes targeted sequencing panels to detect mutations and copy-number alterations for B- and NK/T-cell lymphomas. |
Cita | Sánchez Beato, M., Méndez, M., Criado Guirado, M.J., Pedrosa, L., Sequero, S., Yanguas-Casás, N.,...,Provencio, M. (2023). A genetic profling guideline to support diagnosis and clinical management of lymphomas. Clinical and Translational Oncology. https://doi.org/10.1007/s12094-023-03307-1. |
Ficheros | Tamaño | Formato | Ver | Descripción |
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A genetic profling.pdf | 1.614Mb | [PDF] | Ver/ | |