dc.creator | García-Domínguez, Daniel J. | es |
dc.creator | López Enriquez, Soledad | es |
dc.creator | Alba Jiménez, Gonzalo | es |
dc.creator | Garnacho Montero, Carmen | es |
dc.creator | Jiménez Cortegana, Carlos | es |
dc.creator | Flores-Campos, Rocío | es |
dc.creator | Cruz Merino, Luis de la | es |
dc.creator | Hajji, Nabil | es |
dc.creator | Sánchez Margalet, Víctor | es |
dc.creator | Hontecillas-Prieto, Lourdes | es |
dc.date.accessioned | 2024-02-23T18:56:46Z | |
dc.date.available | 2024-02-23T18:56:46Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | García-Domínguez, D.J., López Enriquez, S., Alba Jiménez, G., Garnacho Montero, C., Jiménez Cortegana, C., Flores-Campos, R.,...,Hontecillas-Prieto, L. (2024). Cancer nano-immunotherapy: the novel and promising weapon to fight cancer. International Journal of Molecular Sciences, 25 (2), 1195. https://doi.org/10.3390/ijms25021195. | |
dc.identifier.issn | 1422-0067 | es |
dc.identifier.uri | https://hdl.handle.net/11441/155560 | |
dc.description.abstract | Cancer is a complex disease that, despite advances in treatment and the greater understanding
of the tumor biology until today, continues to be a prevalent and lethal disease. Chemotherapy,
radiotherapy, and surgery are the conventional treatments, which have increased the survival for
cancer patients. However, the complexity of this disease together with the persistent problems due
to tumor progression and recurrence, drug resistance, or side effects of therapy make it necessary to
explore new strategies that address the challenges to obtain a positive response. One important point is
that tumor cells can interact with the microenvironment, promoting proliferation, dissemination, and
immune evasion. Therefore, immunotherapy has emerged as a novel therapy based on the modulation
of the immune system for combating cancer, as reflected in the promising results both in preclinical
studies and clinical trials obtained. In order to enhance the immune response, the combination of
immunotherapy with nanoparticles has been conducted, improving the access of immune cells to
the tumor, antigen presentation, as well as the induction of persistent immune responses. Therefore,
nanomedicine holds an enormous potential to enhance the efficacy of cancer immunotherapy. Here,
we review the most recent advances in specific molecular and cellular immunotherapy and in nano immunotherapy against cancer in the light of the latest published preclinical studies and clinical trials. | es |
dc.description.sponsorship | Junta de Andalucía | es |
dc.format | application/pdf | es |
dc.format.extent | 23 p. | es |
dc.language.iso | eng | es |
dc.publisher | Mdpi Ag | es |
dc.relation.ispartof | International Journal of Molecular Sciences, 25 (2), 1195. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Cancer | es |
dc.subject | Immunotherapy | es |
dc.subject | Nanomedicine | es |
dc.subject | Clinical trials | es |
dc.title | Cancer nano-immunotherapy: the novel and promising weapon to fight cancer | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/25/2/1195 | es |
dc.identifier.doi | 10.3390/ijms25021195 | es |
dc.journaltitle | International Journal of Molecular Sciences | es |
dc.publication.volumen | 25 | es |
dc.publication.issue | 2 | es |
dc.publication.initialPage | 1195 | es |