Artículo
Dendritic cells as a therapeutic strategy in acute myeloid leukemia: vaccines
Autor/es | Palomares, Francisca
![]() ![]() ![]() ![]() Pina, Alejandra Dakhaoui, Hala Leiva Castro, Camila Munera Rodríguez, Ana M. Cejudo Guillén, Marta ![]() ![]() ![]() ![]() ![]() ![]() Alba Jiménez, Gonzalo ![]() ![]() ![]() ![]() ![]() ![]() Santa-María Pérez, Consuelo ![]() ![]() ![]() ![]() ![]() ![]() López Enríquez, Soledad |
Departamento | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología Universidad de Sevilla. Departamento de Farmacología, Pediatría y Radiología |
Fecha de publicación | 2024-02 |
Fecha de depósito | 2024-02-22 |
Publicado en |
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Resumen | Dendritic cells (DCs) serve as professional antigen-presenting cells (APC) bridging innate and adaptive immunity, playing an essential role in triggering specific cellular and humoral responses against tumor and infectious ... Dendritic cells (DCs) serve as professional antigen-presenting cells (APC) bridging innate and adaptive immunity, playing an essential role in triggering specific cellular and humoral responses against tumor and infectious antigens. Consequently, various DC-based antitumor therapeutic strategies have been developed, particularly vaccines, and have been intensively investigated specifically in the context of acute myeloid leukemia (AML). This hematological malignancy mainly affects the elderly population (those aged over 65), which usually presents a high rate of therapeutic failure and an unfavorable prognosis. In this review, we examine the current state of development and progress of vaccines in AML. The findings evidence the possible administration of DC-based vaccines as an adjuvant treatment in AML following initial therapy. Furthermore, the therapy demonstrates promising outcomes in preventing or delaying tumor relapse and exhibits synergistic effects when combined with other treatments during relapses or disease progression. On the other hand, the remarkable success observed with RNA vaccines for COVID-19, delivered in lipid nanoparticles, has revealed the efficacy and effectiveness of these types of vectors, prompting further exploration and their potential application in AML, as well as other neoplasms, loading them with tumor RNA. |
Agencias financiadoras | Universidad de Sevilla |
Identificador del proyecto | USE VII-PPI 2022/00000421
![]() USE VII-PPI 2023/00000482 ![]() |
Cita | Palomares, F., Pina, A., Dakhaoui, H., Leiva Castro, C., Munera Rodríguez, A.M., Cejudo Guillén, M.,...,López Enríquez, . (2024). Dendritic cells as a therapeutic strategy in acute myeloid leukemia: vaccines. Vaccines, 12 (2). https://doi.org/10.3390/vaccines12020165. |
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