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Artículo
Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment
dc.creator | Skwierawska, Dominika | es |
dc.creator | López-Valverde, José Antonio | es |
dc.creator | Balcerzyk, Marcin | es |
dc.creator | Leal Plaza, Antonio | es |
dc.date.accessioned | 2024-02-15T16:01:51Z | |
dc.date.available | 2024-02-15T16:01:51Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Skwierawska, D., López-Valverde, J.A., Balcerzyk, M. y Leal Plaza, A. (2022). Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment. cancers, 14 (12), 2865. https://doi.org/10.3390/cancers14122865. | |
dc.identifier.issn | 2072-6694 | es |
dc.identifier.uri | https://hdl.handle.net/11441/155286 | |
dc.description.abstract | bstract: Boron Neutron Capture Therapy (BNCT) is a promising binary disease-targeted therapy, as neutrons preferentially kill cells labeled with boron (10B), which makes it a precision medicine treatment modality that provides a therapeutic effect exclusively on patient-specific tumor spread. Contrary to what is usual in radiotherapy, BNCT proposes cell-tailored treatment planning rather than to the tumor mass. The success of BNCT depends mainly on the sufficient spatial biodistribution of 10B located around or within neoplastic cells to produce a high-dose gradient between the tumor and healthy tissue. However, it is not yet possible to precisely determine the concentration of 10B in a specific tissue in real-time using non-invasive methods. Critical issues remain to be resolved if BNCT is to become a valuable, minimally invasive, and efficient treatment. In addition, functional imaging technologies, such as PET, can be applied to determine biological information that can be used for the combined-modality radiotherapy protocol for each specific patient. Regardless, not only imaging methods but also proteomics and gene expression methods will facilitate BNCT becoming a modality of personalized medicine. This work provides an overview of the fundamental principles, recent advances, and future directions of BNCT as cell-targeted cancer therapy for personalized radiation treatment. | es |
dc.format | application/pdf | es |
dc.format.extent | 26 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | cancers, 14 (12), 2865. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | BNCT | es |
dc.subject | Targeted therapy | es |
dc.subject | Biological dosimetry | es |
dc.subject | Boron imaging | es |
dc.subject | Personalized oncology | es |
dc.subject | Personalized medicine | es |
dc.title | Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.relation.publisherversion | https://www.mdpi.com/2072-6694/14/12/2865 | es |
dc.identifier.doi | 10.3390/cancers14122865 | es |
dc.journaltitle | cancers | es |
dc.publication.volumen | 14 | es |
dc.publication.issue | 12 | es |
dc.publication.initialPage | 2865 | es |