Article
Impact of Sphingolipids on Protein Membrane Trafficking
Author/s | Aguilera Romero, María Auxiliadora
![]() ![]() ![]() ![]() ![]() ![]() Lucena Hernández, Rafael ![]() ![]() ![]() ![]() ![]() ![]() ![]() Sabido Bozo, Susana Muñiz Guinea, Manuel ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
Department | Universidad de Sevilla. Departamento de Biología Celular |
Publication Date | 2023 |
Deposit Date | 2024-02-15 |
Published in |
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Abstract | Membrane trafficking is essential to maintain the spatiotemporal control of protein and lipid distribution within membrane systems of eukaryotic cells. To achieve their functional destination proteins are sorted and ... Membrane trafficking is essential to maintain the spatiotemporal control of protein and lipid distribution within membrane systems of eukaryotic cells. To achieve their functional destination proteins are sorted and transported into lipid carriers that construct the secretory and endocytic pathways. It is an emerging theme that lipid diversity might exist in part to ensure the homeostasis of these pathways. Sphingolipids, a chemical diverse type of lipids with special physicochemical characteristics have been implicated in the selective transport of proteins. In this review, we will discuss current knowledge about how sphingolipids modulate protein trafficking through the endomembrane systems to guarantee that proteins reach their functional destination and the proposed underlying mechanisms. |
Funding agencies | Junta de Andalucía Ministerio de Educación, Cultura y Deporte (MECD). España |
Project ID. | US-1380893
![]() P18-FRJ-1132 ![]() |
Citation | Aguilera Romero, M.A., Lucena Hernández, R., Sabido Bozo, S. y Muñiz Guinea, M. (2023). Impact of Sphingolipids on Protein Membrane Trafficking. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1868 (8), 159334. https://doi.org/10.1016/j.bbalip.2023.159334. |
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