dc.creator | Villanueva, Álvaro | es |
dc.creator | Rivero Pino, Fernando | es |
dc.creator | Martín Rubio, María Esther | es |
dc.creator | González de la Rosa, Teresa | es |
dc.creator | Montserrat de la Paz, Sergio | es |
dc.creator | Millán Linares , Carmen | es |
dc.date.accessioned | 2024-02-12T15:19:09Z | |
dc.date.available | 2024-02-12T15:19:09Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | Villanueva, Á., Rivero Pino, F., Martín Rubio, M.E., González de la Rosa, T., Montserrat de la Paz, S. y Millán Linares , C. (2024). Identification of the Bioavailable Peptidome of Chia Protein Hydrolysate and the In Silico Evaluation of Its Antioxidant and ACE Inhibitory Potential. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/acs.jafc.3c05331. | |
dc.identifier.issn | 0021-8561 | es |
dc.identifier.issn | 1520-5118 | es |
dc.identifier.uri | https://hdl.handle.net/11441/155169 | |
dc.description.abstract | The incorporation of novel, functional, and sustainable foods in human diets is increasing because of their beneficial
effects and environmental-friendly nature. Chia (Salvia hispanica L.) has proved to be a suitable source of bioactive peptides via
enzymatic hydrolysis. These peptides could be responsible for modulating several physiological processes if able to reach the target
organ. The bioavailable peptides contained in a hydrolysate obtained with Alcalase, as functional foods, were identified using a
transwell system with Caco-2 cell culture as the absorption model. Furthermore, 20 unique peptides with a molecular weight lower
than 1000 Da and the higher statistical significance of the peptide-precursor spectrum match (−10 log P) were assessed by in silico
tools to suggest which peptides could be those exerting the demonstrated bioactivity. From the characterized peptides, considering
the molecular features and the results obtained, the peptides AGDAHWTY, VDAHPIKAM, PNYHPNPR, and ALPPGAVHW are
anticipated to be contributing to the antioxidant and/or ACE inhibitor activity of the chia protein hydrolysates. | es |
dc.description.sponsorship | Junta de Andalucía P20_00661 | es |
dc.description.sponsorship | Fondo Europeo de Desarrollo Regional US-1381492 | es |
dc.format | application/pdf | es |
dc.format.extent | 11 p. | es |
dc.language.iso | eng | es |
dc.publisher | American Chemical Society | es |
dc.relation.ispartof | Journal of Agricultural and Food Chemistry. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | ACE | es |
dc.subject | Bioactive peptides | es |
dc.subject | DPPH | es |
dc.subject | Identification | es |
dc.subject | Rotease | es |
dc.subject | Subtilisin | es |
dc.title | Identification of the Bioavailable Peptidome of Chia Protein Hydrolysate and the In Silico Evaluation of Its Antioxidant and ACE Inhibitory Potential | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Biología Celular | es |
dc.relation.projectID | P20_00661 | es |
dc.relation.projectID | US-1381492 | es |
dc.relation.publisherversion | https://doi.org/10.1021/acs.jafc.3c05331 | es |
dc.identifier.doi | 10.1021/acs.jafc.3c05331 | es |
dc.journaltitle | Journal of Agricultural and Food Chemistry | es |
dc.contributor.funder | Junta de Andalucía | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |