dc.contributor.advisor | | |
dc.creator | Torres, E. | es |
dc.creator | López Cerero, Lorena | es |
dc.creator | Navarro, M. D. | es |
dc.creator | Rodríguez-Baño, Jesús | es |
dc.creator | Pascual Hernández, Álvaro | es |
dc.date.accessioned | 2024-02-01T13:45:10Z | |
dc.date.available | 2024-02-01T13:45:10Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Torres, E., López Cerero, L., Navarro, M.D., Rodríguez-Baño, J. y Pascual Hernández, Á. (2018). Prevalence and transmission dynamics of Escherichia coli ST131 among contacts of infected community and hospitalized patients. Clinical Microbiology and Infection (CMI), 24 (6), 618-623. https://doi.org/10.1016/j.cmi.2017.09.007. | |
dc.identifier.issn | 1198-743X | es |
dc.identifier.issn | 1469-0691 | es |
dc.identifier.uri | https://hdl.handle.net/11441/154428 | |
dc.description.abstract | Objectives: The Escherichia coli O25b-associated ST131 clonal group was recently found to be prevalent in our area as a cause of community-acquired urinary tract infections. We evaluated the transmission dynamics and longitudinal persistence of E. coli O25b-ST131 between patients with nosocomial and community-acquired infections and their contacts.
Methods: Prevalence and transmission of O25b/pabB3/B23 isolates were compared in 38 community clusters, 30 nosocomial clusters and 50 healthy volunteers. Duration of colonization was studied at 1 to 4 months and 6 to 12 months after the first sample. Isolates exhibiting a three-band or less difference by pulsed-field gel electrophoresis were assigned to the same pulsotype.
Results: Colonization was found to be more frequent in index cases (31/68, 45.6%) than in contacts (25/118, 21.2%; p 0.0009) or volunteers (1/50, 2%; p 0.0009). Seven (11%) of 64 isolates were extended-spectrum β-lactamase producers. Transmission occurred in 61% (8/13) community clusters and in 12% (1/8) nosocomial clusters. Thirteen (56.5%) of the 23 initial carriers assessed at 1 to 4 months remained colonized. Only 2 (13.3%) of 15 positive patients followed for 6 to 12 months showed prolonged carriage, and none was infected with extended-spectrum β-lactamase producers. Six previously positive individuals acquired a different ST131 pulsotype (5/23 at sample 2 and 1/15 at sample 3), and three previously negative individuals became positive (2/46 at 1-4 months and 1/33 at 6-12 months).
Conclusions: Person-to-person transmission or acquisition from a common source of E. coli O25b-associated ST131 is more frequent in the household setting than in the nosocomial setting. The carrier state does not usually last beyond 4 months, with new acquisitions in certain individuals. | es |
dc.format | application/pdf | es |
dc.format.extent | 6 p. | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Clinical Microbiology and Infection (CMI), 24 (6), 618-623. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Escherichia coli | es |
dc.subject | Horizontal transmission | es |
dc.subject | Intestinal carriage | es |
dc.subject | Intestinal persistence | es |
dc.subject | ST131 | es |
dc.title | Prevalence and transmission dynamics of Escherichia coli ST131 among contacts of infected community and hospitalized patients | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Microbiología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.contributor.affiliation | Universidad de Sevilla. Instituto de Biomedicina de Sevilla (IBIS) | |
dc.relation.projectID | 115523 | es |
dc.relation.projectID | 115620 | es |
dc.relation.projectID | 115737 | es |
dc.relation.projectID | 070190 | es |
dc.relation.projectID | 10/02021 | es |
dc.relation.projectID | 10/01955 | es |
dc.relation.projectID | 10/00795 | es |
dc.relation.projectID | 0048/2008 | es |
dc.relation.projectID | CTX-5259 | es |
dc.relation.projectID | CTS210 | es |
dc.relation.projectID | REIPI RD12/0015/0010 | es |
dc.relation.projectID | REIPI RD16/0016/0001 | es |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S1198743X17305050?via%3Dihub | es |
dc.identifier.doi | 10.1016/j.cmi.2017.09.007 | es |
dc.journaltitle | Clinical Microbiology and Infection (CMI) | es |
dc.publication.volumen | 24 | es |
dc.publication.issue | 6 | es |
dc.publication.initialPage | 618 | es |
dc.publication.endPage | 623 | es |
dc.contributor.funder | EFPIA | es |
dc.contributor.funder | European Development Regional Fund | es |
dc.contributor.funder | European Union | es |
dc.contributor.funder | Fondo de Investigacion Sanitaria | es |
dc.contributor.funder | Industria y Competitividad | es |
dc.contributor.funder | Innovative Medicines Initiative | es |
dc.contributor.funder | Instituto de Salud Carlos III | es |
dc.contributor.funder | Junta de Andalucia | es |
dc.contributor.funder | Ministerio de Economia | es |
dc.contributor.funder | Operative Programme INtelligent Growth | es |
dc.contributor.funder | Plan Nacional de I+D+i | es |
dc.contributor.funder | Spanish Network for Research in Infectious Diseases | es |
dc.contributor.funder | Subdireccion General de Redes y Centros de Investigacion Cooperativa | es |