dc.creator | Alcarranza Saucedo, Manuel | es |
dc.creator | Villegas Lama, Isabel | es |
dc.creator | Recio Jiménez, Rocío | es |
dc.creator | Muñoz García, Rocío | es |
dc.creator | Fernández Fernández, Inmaculada | es |
dc.creator | Alarcón de la Lastra Romero, Catalina | es |
dc.date.accessioned | 2024-01-29T12:51:06Z | |
dc.date.available | 2024-01-29T12:51:06Z | |
dc.date.issued | 2023-07-20 | |
dc.identifier.citation | Alcarranza Saucedo, M., Villegas Lama, I., Recio Jiménez, R., Muñoz García, R., Fernández Fernández, I. y Alarcón de la Lastra Romero, C. (2023). (R)-8-Methylsulfinyloctyl isothiocyanate from Nasturtium officinale inhibits LPS-induced immunoinflammatory responses in mouse peritoneal macrophages: chemical synthesis and molecular signaling pathways involved. Food and Function, 14 (15), 7270-7283. https://doi.org/10.1039/D3FO02009F. | |
dc.identifier.issn | 2042-6496 | es |
dc.identifier.issn | 2042-650X | es |
dc.identifier.uri | https://hdl.handle.net/11441/154152 | |
dc.description.abstract | The aim of this study was to develop an optimal synthetic route to obtain natural (R)-8-methylsulfinyloctyl
isothiocyanate ((R)-8-OITC), present in watercress, based on the “DAG methodology” as well as to evaluate its potential antioxidant and immunomodulatory effects, exploring possible signaling pathways that
could be involved in an ex vivo model of murine peritoneal macrophages stimulated with LPS. Treatment
with (R)-8-OITC inhibited the levels of pro-inflammatory cytokines (IL-1β, TNF-α, IL-6, IL-17 and IL-18),
intracellular ROS production and expression of pro-inflammatory enzymes (COX-2, iNOS and mPGES-1)
through modulation of the expression of Nrf2, MAPKs (p38, JNK and ERK) and JAK/STAT, and the canonical and non-canonical pathways of the inflammasome. Taking all these together, our results provide a
rapid and cost-effective synthetic route to obtain natural (R)-8-OITC and demonstrate that it could be a
potential nutraceutical candidate for managing immuno-inflammatory pathologies. Therefore, further
in vivo trials are warranted. | es |
dc.description.sponsorship | Ministerio de Ciencia, Innovación y Universidades de España - PID2019-104767RB-I00/AEI/10.13039/501100011033 | es |
dc.description.sponsorship | Consejería de Transformación Económica, Industria, Beca Conocimiento y Universidad, Junta de Andalucía - P20-01171 y FQM-102 | es |
dc.description.sponsorship | Consejería de Economía, Conocimiento, Empresas y Universidad, Junta de Andalucía -2021/CTS-259 | es |
dc.format | application/pdf | es |
dc.format.extent | 14 p. | es |
dc.language.iso | eng | es |
dc.publisher | Royal Society of Chemistry | es |
dc.relation.ispartof | Food and Function, 14 (15), 7270-7283. | |
dc.rights | Attribution-NoDerivatives 4.0 Internacional | * |
dc.rights | Atribución-NoComercial 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.title | (R)-8-Methylsulfinyloctyl isothiocyanate from Nasturtium officinale inhibits LPS-induced immunoinflammatory responses in mouse peritoneal macrophages: chemical synthesis and molecular signaling pathways involved | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica | es |
dc.relation.projectID | PID2019-104767RB-I00/AEI/10.13039/501100011033 | es |
dc.relation.projectID | P20-01171 | es |
dc.relation.projectID | FQM-102 | es |
dc.relation.projectID | 2021/CTS-259 | es |
dc.relation.publisherversion | https://doi.org/10.1039/D3FO02009F | es |
dc.identifier.doi | 10.1039/D3FO02009F | es |
dc.contributor.group | Universidad de Sevilla. FQM102: Estereoquímica y Síntesis Asimétrica | es |
dc.contributor.group | Universidad de Sevilla. CTS259: Farmacología Experimental y Farmacia Clínica | es |
dc.journaltitle | Food and Function | es |
dc.publication.volumen | 14 | es |
dc.publication.issue | 15 | es |
dc.publication.initialPage | 7270 | es |
dc.publication.endPage | 7283 | es |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (MICINN). España | es |
dc.contributor.funder | Junta de Andalucía | es |