Artículo
(R)-8-Methylsulfinyloctyl isothiocyanate from Nasturtium officinale inhibits LPS-induced immunoinflammatory responses in mouse peritoneal macrophages: chemical synthesis and molecular signaling pathways involved
Autor/es | Alcarranza Saucedo, Manuel
Villegas Lama, Isabel Recio Jiménez, Rocío Muñoz García, Rocío Fernández Fernández, Inmaculada Alarcón de la Lastra Romero, Catalina |
Departamento | Universidad de Sevilla. Departamento de Farmacología Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica |
Fecha de publicación | 2023-07-20 |
Fecha de depósito | 2024-01-29 |
Publicado en |
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Resumen | The aim of this study was to develop an optimal synthetic route to obtain natural (R)-8-methylsulfinyloctyl
isothiocyanate ((R)-8-OITC), present in watercress, based on the “DAG methodology” as well as to evaluate its ... The aim of this study was to develop an optimal synthetic route to obtain natural (R)-8-methylsulfinyloctyl isothiocyanate ((R)-8-OITC), present in watercress, based on the “DAG methodology” as well as to evaluate its potential antioxidant and immunomodulatory effects, exploring possible signaling pathways that could be involved in an ex vivo model of murine peritoneal macrophages stimulated with LPS. Treatment with (R)-8-OITC inhibited the levels of pro-inflammatory cytokines (IL-1β, TNF-α, IL-6, IL-17 and IL-18), intracellular ROS production and expression of pro-inflammatory enzymes (COX-2, iNOS and mPGES-1) through modulation of the expression of Nrf2, MAPKs (p38, JNK and ERK) and JAK/STAT, and the canonical and non-canonical pathways of the inflammasome. Taking all these together, our results provide a rapid and cost-effective synthetic route to obtain natural (R)-8-OITC and demonstrate that it could be a potential nutraceutical candidate for managing immuno-inflammatory pathologies. Therefore, further in vivo trials are warranted. |
Agencias financiadoras | Ministerio de Ciencia, Innovación y Universidades (MICINN). España Junta de Andalucía |
Identificador del proyecto | PID2019-104767RB-I00/AEI/10.13039/501100011033
P20-01171 FQM-102 2021/CTS-259 |
Cita | Alcarranza Saucedo, M., Villegas Lama, I., Recio Jiménez, R., Muñoz García, R., Fernández Fernández, I. y Alarcón de la Lastra Romero, C. (2023). (R)-8-Methylsulfinyloctyl isothiocyanate from Nasturtium officinale inhibits LPS-induced immunoinflammatory responses in mouse peritoneal macrophages: chemical synthesis and molecular signaling pathways involved. Food and Function, 14 (15), 7270-7283. https://doi.org/10.1039/D3FO02009F. |
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