dc.creator | Martínez Muñoz, Guillermo | es |
dc.creator | Begines Ruiz, Belén | es |
dc.creator | Pajuelo Domínguez, Eloísa | es |
dc.creator | Vázquez Cabello, Juan | es |
dc.creator | Rodríguez-Albelo, Luisa Marleny | es |
dc.creator | Cofini, Davide | es |
dc.creator | Torres Hernández, Yadir | es |
dc.creator | Alcudia Cruz, Ana | es |
dc.date.accessioned | 2023-11-27T11:11:31Z | |
dc.date.available | 2023-11-27T11:11:31Z | |
dc.date.issued | 2023-09 | |
dc.identifier.citation | Martínez Muñoz, G., Begines Ruiz, B., Pajuelo Domínguez, E., Vázquez Cabello, J., Rodríguez-Albelo, L.M., Cofini, D.,...,Alcudia Cruz, A. (2023). Versatile Biodegradable Poly(acrylic acid)-Based Hydrogels Infiltrated in Porous Titanium Implants to Improve the Biofunctional Performance. Biomacromolecules, 24 (11), 4743-4758. https://doi.org/10.1021/acs.biomac.3c00532. | |
dc.identifier.issn | 1525-7797 | es |
dc.identifier.issn | 1526-4602 | es |
dc.identifier.uri | https://hdl.handle.net/11441/151643 | |
dc.description.abstract | This research work proposes a synergistic approach to
improve implants’ performance through the use of porous Ti substrates
to reduce the mismatch between Young’s modulus of Ti (around 110
GPa) and the cortical bone (20−25 GPa), and the application of a
biodegradable, acrylic acid-based polymeric coating to reduce bacterial
adhesion and proliferation, and to enhance osseointegration. First,
porous commercially pure Ti substrates with different porosities and
pore size distributions were fabricated by using space-holder techniques
to obtain substrates with improved tribomechanical behavior. On the
other hand, a new diacrylate cross-linker containing a reductionsensitive
disulfide bond was synthesized to prepare biodegradable
poly(acrylic acid)-based hydrogels with 1, 2, and 4% cross-linker.
Finally, after the required characterization, both strategies were
implemented, and the combination of 4% cross-linked poly(acrylic acid)-based hydrogel infiltrated in 30 vol % porosity, 100−
200 μm average pore size, was revealed as an outstanding choice for enhancing implant performance. | es |
dc.format | application/pdf | es |
dc.format.extent | 16 p. | es |
dc.language.iso | eng | es |
dc.publisher | American Chemical Society | es |
dc.relation.ispartof | Biomacromolecules, 24 (11), 4743-4758. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Versatile Biodegradable Poly(acrylic acid)-Based Hydrogels Infiltrated in Porous Titanium Implants to Improve the Biofunctional Performance | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Microbiología y Parasitología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química Orgánica | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte | es |
dc.relation.projectID | US-1380878 | es |
dc.relation.projectID | PID2019-109371GB-I00 | es |
dc.relation.projectID | PDC2022-133369-I00 | es |
dc.relation.projectID | VII-PPITUS 2022/00000332 | es |
dc.relation.projectID | VII-PPITUS 2022/00000277 | es |
dc.relation.publisherversion | https://pubs.acs.org/doi/full/10.1021/acs.biomac.3c00532 | es |
dc.identifier.doi | 10.1021/acs.biomac.3c00532 | es |
dc.contributor.group | Universidad de Sevilla. FQM408: Química Farmacéutica Aplicada | es |
dc.contributor.group | Universidad de Sevilla. BIO181: Fitomicrobiomas como Herramientas Biotecnológicas | es |
dc.contributor.group | Universidad de Sevilla. TEP123: Metalurgia e Ingeniería de los Materiales | es |
dc.journaltitle | Biomacromolecules | es |
dc.publication.volumen | 24 | es |
dc.publication.issue | 11 | es |
dc.publication.initialPage | 4743 | es |
dc.publication.endPage | 4758 | es |
dc.contributor.funder | Junta de Andalucía and FEDER Andalucía US-1380878 | es |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) PID2019-109371GB-I00 | es |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) PDC2022-133369-I00 | es |
dc.contributor.funder | VII Plan Propio de Investigación y Transferencia-Universidad de Sevilla 2022/00000332 | es |
dc.contributor.funder | VII Plan Propio de Investigación y Transferencia-Universidad de Sevilla 2022/00000277 | es |
dc.description.awardwinning | Premio Anual Publicación Científica Destacada de la US. Facultad de Farmacia | |