Artículo
Versatile Biodegradable Poly(acrylic acid)-Based Hydrogels Infiltrated in Porous Titanium Implants to Improve the Biofunctional Performance
Autor/es | Martínez Muñoz, Guillermo
Begines Ruiz, Belén Pajuelo Domínguez, Eloísa Vázquez Cabello, Juan Rodríguez-Albelo, Luisa Marleny Cofini, Davide Torres Hernández, Yadir Alcudia Cruz, Ana |
Departamento | Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica Universidad de Sevilla. Departamento de Microbiología y Parasitología Universidad de Sevilla. Departamento de Química Orgánica Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte |
Fecha de publicación | 2023-09 |
Fecha de depósito | 2023-11-27 |
Publicado en |
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Premios | Premio Anual Publicación Científica Destacada de la US. Facultad de Farmacia |
Resumen | This research work proposes a synergistic approach to
improve implants’ performance through the use of porous Ti substrates
to reduce the mismatch between Young’s modulus of Ti (around 110
GPa) and the cortical bone ... This research work proposes a synergistic approach to improve implants’ performance through the use of porous Ti substrates to reduce the mismatch between Young’s modulus of Ti (around 110 GPa) and the cortical bone (20−25 GPa), and the application of a biodegradable, acrylic acid-based polymeric coating to reduce bacterial adhesion and proliferation, and to enhance osseointegration. First, porous commercially pure Ti substrates with different porosities and pore size distributions were fabricated by using space-holder techniques to obtain substrates with improved tribomechanical behavior. On the other hand, a new diacrylate cross-linker containing a reductionsensitive disulfide bond was synthesized to prepare biodegradable poly(acrylic acid)-based hydrogels with 1, 2, and 4% cross-linker. Finally, after the required characterization, both strategies were implemented, and the combination of 4% cross-linked poly(acrylic acid)-based hydrogel infiltrated in 30 vol % porosity, 100− 200 μm average pore size, was revealed as an outstanding choice for enhancing implant performance. |
Agencias financiadoras | Junta de Andalucía and FEDER Andalucía US-1380878 Ministerio de Ciencia, Innovación y Universidades (España) PID2019-109371GB-I00 Ministerio de Ciencia, Innovación y Universidades (España) PDC2022-133369-I00 VII Plan Propio de Investigación y Transferencia-Universidad de Sevilla 2022/00000332 VII Plan Propio de Investigación y Transferencia-Universidad de Sevilla 2022/00000277 |
Identificador del proyecto | US-1380878
PID2019-109371GB-I00 PDC2022-133369-I00 VII-PPITUS 2022/00000332 VII-PPITUS 2022/00000277 |
Cita | Martínez Muñoz, G., Begines Ruiz, B., Pajuelo Domínguez, E., Vázquez Cabello, J., Rodríguez-Albelo, L.M., Cofini, D.,...,Alcudia Cruz, A. (2023). Versatile Biodegradable Poly(acrylic acid)-Based Hydrogels Infiltrated in Porous Titanium Implants to Improve the Biofunctional Performance. Biomacromolecules, 24 (11), 4743-4758. https://doi.org/10.1021/acs.biomac.3c00532. |
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