Artículo
Anxiolytic-like effects of Lupinus angustifolious protein hydrolysates in alzheimer model mice
Autor/es | Santos Sánchez, Guillermo
Ponce España, Eduardo Cruz Chamorro, Iván López García, Juan Carlos Álvarez López, Ana Isabel Pedroche, Justo Millán-Linares, María del Carmen Millán, Francisco Lardone, Patricia Judith Bejarano Hernando, Ignacio Guerrero Montávez, Juan Miguel Carrillo Vico, Antonio |
Departamento | Universidad de Sevilla. Departamento de Psicología Experimental Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología |
Fecha de publicación | 2021 |
Fecha de depósito | 2023-11-17 |
Publicado en |
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Resumen | Alzheimer’s disease (AD), which is characterized by a devastating and progressive loss of memory, is the principal neurodegenerative disease in the elderly population worldwide. As a consequence, AD patients present ... Alzheimer’s disease (AD), which is characterized by a devastating and progressive loss of memory, is the principal neurodegenerative disease in the elderly population worldwide. As a consequence, AD patients present neuropsychiatric symptoms, such as anxiety, causing sleeping difficulty, irritability, agitation, or aggressiveness. Previous studies have demonstrated that a high-fat diet, in addition to exacerbating AD, aggravates anxiety. We have demonstrated that Lupinus angustifolius protein hydrolysates (LPHs) have anti-inflammatory and antioxidant effects, key factors for AD and anxiety. Thus, this study aimed to evaluate the potential effects of LPHs on spatial memory and anxiety of a preclinical model of AD. ApoE−/− mice fed with a western diet were intragastrically treated with LPHs (or a vehicle) for 14 weeks. Spatial memory and anxiety were then assessed through the Morris water maze and elevated plus maze, respectively. The results did not show significant differences in spatial memory between groups. However, a significant increase (p < 0.05) in time in open arms, center time, the number of crossings, and a reduction of anxiety behavior were observed in LPH-treated mice. This is the first study showing that an LPH treatment causes anxiolytic effects, pointing to LPHs as a potential component of future nutritional therapies. |
Agencias financiadoras | Ministerio de Economía y Competitividad (MINECO). España Ministerio de Salud del Gobierno Andaluz Gobierno Andaluz Ministerio de Educación, Cultura y Deporte (MECD). España Universidad de Sevilla |
Identificador del proyecto | AGL2012-40247-C02-01
AGL2012-40247-C02-02 PC-0111-2016-0111 CTS160 FPU16/02339 FPU13/01210 VI PPIT-US |
Cita | Santos Sánchez, G., Ponce España, E., Cruz Chamorro, I., López García, J.C., Álvarez López, A.I., Pedroche, J.,...,Carrillo Vico, A. (2021). Anxiolytic-like effects of Lupinus angustifolious protein hydrolysates in alzheimer model mice. Proceedings, 70 (1), 41, 1-6. https://doi.org/10.3390/foods_2020-07685. |
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