dc.creator | Romero Garcia, Rafael | es |
dc.creator | Yaara, Erez | es |
dc.creator | Oliver, Geoffrey | es |
dc.creator | Owen, Mallory | es |
dc.creator | Merali, Sakinah | es |
dc.creator | Poologaindran, Anujan | es |
dc.creator | Hart, Michael G. | es |
dc.date.accessioned | 2023-10-10T11:43:09Z | |
dc.date.available | 2023-10-10T11:43:09Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Romero Garcia, R., Yaara, E., Oliver, G., Owen, M., Merali, S., Poologaindran, A. y Hart, M.G. (2020). Practical Application of Networks in Neurosurgery: Combined 3-Dimensional Printing, Neuronavigation, and Preoperative Surgical Planning. World Neurosurgery, 137, e126-e137. https://doi.org/10.1016/j.wneu.2020.01.085. | |
dc.identifier.issn | 1878-8750 | es |
dc.identifier.issn | 1878-8769 | es |
dc.identifier.uri | https://hdl.handle.net/11441/149626 | |
dc.description.abstract | BACKGROUND: A plethora of cutting-edge neuroimaging analyses have been developed and published, yet they have
not hitherto been realized as improvements in neurosurgical outcomes. In this paper we propose a novel interface be-
tween neuroimaging and neurosurgery for aiding translational research. Our objective is to create a method for
applying advanced neuroimaging and network analysis findings to neurosurgery and illustrate its application
through the presentation of 2 detailed case vignettes.
METHODS: This interface comprises a combination of network visualization, 3-dimensional printing, and ex-vivo
neuronavigation to enable preoperative planning according to functional neuroanatomy. Clinical cases were
selected from a prospective cohort study.
RESULTS: The first case vignette describes a low-grade glioma with potential language and executive function network involvement that underwent a successful complete resection of the lesion with preservation of network features. The second case describes a low-grade glioma in an apparently noneloquent location that underwent a subtotal resection but demonstrated unexpected and significant impairment in executive function postoperatively that subsequently abated during follow-up. In both examples the neuroimaging and network data highlight the complexity of the surrounding functional neuroanatomy at the individual level, beyond that which can be perceived on standard structural sequences.
CONCLUSIONS: The described interface has widespread applications for translational research including preoperative planning, neurosurgical training, and detailed patient counseling. A protocol for assessing its effectiveness and safety is proposed. Finally, recommendations for
effective translation of findings from neuroimaging to neurosurgery are discussed, with the aim of making clinically meaningful improvements to neurosurgical practice. | es |
dc.description.sponsorship | Alan Turing Institute Doctoral Scholarship | es |
dc.description.sponsorship | Brain Post-Doctoral Fellowship award | es |
dc.description.sponsorship | Brain Tumour Charity RG86218 | es |
dc.description.sponsorship | MRC MC_UU_00005/6 | es |
dc.description.sponsorship | National Institute for Health Research (NIHR) (UK)Clinician Scientist Award NIHR/CS/009/011 | es |
dc.description.sponsorship | Royal Society Dorothy Hodgkin Research Fellowship | es |
dc.format | application/pdf | es |
dc.format.extent | 12 | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | World Neurosurgery, 137, e126-e137. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Connectome | es |
dc.subject | Functional connectivity | es |
dc.subject | Imaging | es |
dc.subject | Networks | es |
dc.subject | Tractography | es |
dc.title | Practical Application of Networks in Neurosurgery: Combined 3-Dimensional Printing, Neuronavigation, and Preoperative Surgical Planning | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.identifier.doi | 10.1016/j.wneu.2020.01.085 | es |
dc.journaltitle | World Neurosurgery | es |
dc.publication.volumen | 137 | es |
dc.publication.initialPage | e126 | es |
dc.publication.endPage | e137 | es |