dc.creator | Shen, Chun | es |
dc.creator | Luo, Quiang | es |
dc.creator | Chamberlain, Samuel R. | es |
dc.creator | Morgan, Sarah | es |
dc.creator | Romero García, Rafael | es |
dc.creator | Du, Jingnan | es |
dc.creator | Sahakian, Barbara J. | es |
dc.date.accessioned | 2023-10-03T12:40:51Z | |
dc.date.available | 2023-10-03T12:40:51Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Shen, C., Luo, Q., Chamberlain, S.R., Morgan, S., Romero García, R., Du, J. y Sahakian, B.J. (2020). What Is the Link Between Attention-Deficit/ Hyperactivity Disorder and Sleep Disturbance? A Multimodal Examination of Longitudinal Relationships and Brain Structure Using Large-Scale Population-Based Cohorts. Biological Psychiatry, 88 (6), 459-469. https://doi.org/10.1016/j.biopsych.2020.03.010. | |
dc.identifier.issn | 0006-3223 | es |
dc.identifier.uri | https://hdl.handle.net/11441/149337 | |
dc.description.abstract | BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) comorbid with sleep disturbances can produce profound disruption in daily life and negatively impact quality of life of both the child and the family. However, the temporal relationship between ADHD and sleep impairment is unclear, as are underlying common brain mechanisms.
METHODS: This study used data from the Quebec Longitudinal Study of Child Development (n = 1601, 52% female) and the Adolescent Brain Cognitive Development Study (n = 3515, 48% female). Longitudinal relationships between symptoms were examined using cross-lagged panel models. Gray matter volume neural correlates were identified using linear regression. The transcriptomic signature of the identified brain-ADHD-sleep relationship was characterized by gene enrichment analysis. Confounding factors, such as stimulant drugs for ADHD and
socioeconomic status, were controlled for.
RESULTS: ADHD symptoms contributed to sleep disturbances at one or more subsequent time points in both cohorts. Lower gray matter volumes in the middle frontal gyrus and inferior frontal gyrus, amygdala, striatum, and insula were associated with both ADHD symptoms and sleep disturbances. ADHD symptoms significantly mediated the link between these structural brain abnormalities and sleep dysregulation, and genes were differentially expressed in the implicated brain regions, including those involved in neurotransmission and circadian entrainment.
CONCLUSIONS: This study indicates that ADHD symptoms and sleep disturbances have common neural correlates, including structural changes of the ventral attention system and frontostriatal circuitry. Leveraging data from large datasets, these results offer new mechanistic insights into this clinically important relationship between ADHD and sleep impairment, with potential implications for neurobiological models and future therapeutic directions. | es |
dc.description.sponsorship | National Natural Science Foundation of China Grant Nos. 81873909 and 81930095 [to QL] | es |
dc.description.sponsorship | National Natural Science Foundation of China Grant Nos. 61932008 and 61772368 [to XZ] | es |
dc.description.sponsorship | National Natural Science Foundation of China Grant No. 91630314 [to JF] | es |
dc.description.sponsorship | Natural Science Foundation of Shanghai Grant No. 17ZR1444400 [to QL] | es |
dc.description.sponsorship | Clare Hall, Uni- versity of Cambridge Visiting Fellowship [to QL] | es |
dc.description.sponsorship | Wellcome Trust Clinical Fellowship Reference No. 110049/Z/15/Z [to SRC] | es |
dc.description.sponsorship | National Key Research and Development Program of China Grant No. 2018YFC0910500 [to XZ] | es |
dc.description.sponsorship | National Key Research and Development Program of China Grant No. 2018YFC1312900 [to JF] | es |
dc.description.sponsorship | Lucy Cavendish College, Univer- sity of Cambridge Henslow Fellowship funded by the Cambridge Philo- sophical Society [to SM] | es |
dc.description.sponsorship | 111 Project Grant No. B18015 [to JF] | es |
dc.description.sponsorship | Key Project of Shanghai Science &Technology Grant No. 16JC1420402 [to JF] | es |
dc.description.sponsorship | Shanghai Municipal Science and Technology Major Project Grant No. 2018SHZDZX01 [to JF] | es |
dc.description.sponsorship | Zhangjiang Lab (to JF) | es |
dc.description.sponsorship | Canada Research Chair (Tier 1) Program Grant No. 950-231862 [to MB] | es |
dc.description.sponsorship | National Institute of Health Research Cambridge Biomedical Research Centre | es |
dc.description.sponsorship | Fondation Lucie et André Chagnon | es |
dc.description.sponsorship | Gouvernement du Québec, Institut de la statistique du Québec | es |
dc.description.sponsorship | Ministère de l’Éducation et de l’En- seignement supérieu | es |
dc.description.sponsorship | Ministère de la Famille | es |
dc.description.sponsorship | Institut de recherche Robert- Sauvé en santé et en sécurité du travail | es |
dc.description.sponsorship | Centre hospitalier universitaire Sainte-Justine | es |
dc.description.sponsorship | Ministère de la Santé et des Services sociaux du Québec | es |
dc.format | application/pdf | es |
dc.format.extent | 11 | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Biological Psychiatry, 88 (6), 459-469. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Attention-deficit/hyperactivity disorder (ADHD) | es |
dc.subject | Development | es |
dc.subject | Dyssomnia | es |
dc.subject | Longitudinal study | es |
dc.subject | Neurodevelopmental, | es |
dc.subject | Parasomnia | es |
dc.title | What Is the Link Between Attention-Deficit/ Hyperactivity Disorder and Sleep Disturbance? A Multimodal Examination of Longitudinal Relationships and Brain Structure Using Large-Scale Population-Based Cohorts | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.identifier.doi | 10.1016/j.biopsych.2020.03.010 | es |
dc.journaltitle | Biological Psychiatry | es |
dc.publication.volumen | 88 | es |
dc.publication.issue | 6 | es |
dc.publication.initialPage | 459 | es |
dc.publication.endPage | 469 | es |