dc.creator | Fitzpatrick, S. F. | es |
dc.creator | Lambden, S. | es |
dc.creator | Macías, David | es |
dc.creator | Puthucheary, Z. | es |
dc.creator | Pietsch, S. | es |
dc.creator | Mendil, L. | es |
dc.date.accessioned | 2023-07-20T10:24:00Z | |
dc.date.available | 2023-07-20T10:24:00Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Fitzpatrick, S.F., Lambden, S., Macías, D., Puthucheary, Z., Pietsch, S. y Mendil, L. (2020). 2-hydroxyglutarate metabolism is altered in an in vivo model of LPS induced endotoxemia. Frontiers in Physiology, 11. https://doi.org/10.3389/fphys.2020.00147. | |
dc.identifier.issn | 1664-042X | es |
dc.identifier.uri | https://hdl.handle.net/11441/148125 | |
dc.description.abstract | The metabolic response to endotoxemia closely mimics those seen in sepsis. Here, we show that the urinary excretion of the metabolite 2-hydroxyglutarate (2HG) is dramatically suppressed following lipopolysaccharide (LPS) administration in vivo, and in human septic patients. We further show that enhanced activation of the enzymes responsible for 2-HG degradation, D- and L-2-HGDH, underlie this effect. To determine the role of supplementation with 2HG, we carried out co-administration of LPS and 2HG. This co-administration in mice modulates a number of aspects of physiological responses to LPS, and in particular, protects against LPS-induced hypothermia. Our results identify a novel role for 2HG in endotoxemia pathophysiology, and suggest that this metabolite may be a critical diagnostic and therapeutic target for sepsis. © Copyright © 2020 Fitzpatrick, Lambden, Macias, Puthucheary, Pietsch, Mendil, McPhail and Johnson. | es |
dc.format | application/pdf | es |
dc.format.extent | 8 p. | es |
dc.language.iso | eng | es |
dc.publisher | Frontiers Media | es |
dc.relation.ispartof | Frontiers in Physiology, 11. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | 2-hydroxyglutarate | es |
dc.subject | 2-hydroxygluterate dehydrogenase | es |
dc.subject | Endotoxemia | es |
dc.subject | hypothermia | es |
dc.subject | INOS | es |
dc.subject | Sepsis | es |
dc.title | 2-hydroxyglutarate metabolism is altered in an in vivo model of LPS induced endotoxemia | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.relation.projectID | WT092738MA | es |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fphys.2020.00147/full | es |
dc.identifier.doi | 10.3389/fphys.2020.00147 | es |
dc.journaltitle | Frontiers in Physiology | es |
dc.publication.volumen | 11 | es |
dc.contributor.funder | Wellcome Trust | es |