dc.creator | Mayo Leon, Francisco | es |
dc.creator | Gonzalez Vinceiro, Lourdes | es |
dc.creator | Hiraldo González, Laura | es |
dc.creator | Calle-Castillejo, Claudia | es |
dc.creator | Morales-Álvarez, Sara | es |
dc.creator | Ramírez Lorca, Reposo | es |
dc.creator | Echevarría Irusta, Miriam | es |
dc.date.accessioned | 2023-06-26T12:32:14Z | |
dc.date.available | 2023-06-26T12:32:14Z | |
dc.date.issued | 2023-02-03 | |
dc.identifier.citation | Mayo Leon, F., Gonzalez Vinceiro, L., Hiraldo Gonzalez, L., Calle-Castillejo, C., Morales-Álvarez, S., Ramírez Lorca, R. y Echevarría Irusta, M. (2023). Aquaporin-4 expression switches from white to gray matter regions during postnatal development of the central nervous system. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (3), 3048. https://doi.org/10.3390/ijms24033048. | |
dc.identifier.issn | 1422-0067 | es |
dc.identifier.uri | https://hdl.handle.net/11441/147488 | |
dc.description.abstract | Aquaporin-4 (AQP4) is the most abundant water channel in the central nervous system
and plays a fundamental role in maintaining water homeostasis there. In adult mice, AQP4 is
located mainly in ependymal cells, in the endfeet of perivascular astrocytes, and in the glia limitans.
Meanwhile, its expression, location, and function throughout postnatal development remain largely
unknown. Here, the expression of AQP4 mRNA was studied by in situ hybridization and RT-qPCR,
and the localization and amount of protein was studied by immunofluorescence and western blotting,
both in the brain and spinal cord. For this, wild-type mice of the C57BL/6 line, aged 1, 3, 7, 11, 20,
and 60 days, and 18 months were used. The results showed a change in both the expression and
location of AQP4 in postnatal development compared to those during adult life. In the early stages
of postnatal development it appears in highly myelinated areas, such as the corpus callosum or
cerebellum, and as the animal grows, it disappears from these areas, passing through the cortical
regions of the forebrain and concentrating around the blood vessels. These findings suggest an
unprecedented possible role for AQP4 in the early cell differentiation process, during the first days of
life in the newborn animal, which will lead to myelination. | es |
dc.format | application/pdf | es |
dc.format.extent | 15 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (3), 3048. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Aquaporins | es |
dc.subject | AQP4 | es |
dc.subject | Central nervous system (CNS) | es |
dc.subject | Gray matter | es |
dc.subject | White matter | es |
dc.subject | Oligodendrocytes | es |
dc.subject | Astrocytes | es |
dc.subject | Oligodendrogenesis | es |
dc.subject | Myelination | es |
dc.title | Aquaporin-4 expression switches from white to gray matter regions during postnatal development of the central nervous system | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.relation.projectID | PI19/01096 | es |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/24/3/3048 | es |
dc.identifier.doi | 10.3390/ijms24033048 | es |
dc.journaltitle | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | es |
dc.publication.volumen | 24 | es |
dc.publication.issue | 3 | es |
dc.publication.initialPage | 3048 | es |
dc.contributor.funder | Ministerio de Economía de España y Competitividad | es |