Artículo
The Effect of the Extra Virgin Olive Oil Minor Phenolic Compound 3',4'-Dihydroxyphenylglycol in Experimental Diabetic Kidney Disease
Autor/es | Rodriguez-Perez, Maria Dolores
Santiago-Corral, Laura Ortega-Hombrados, Laura Verdugo, Cristina Arrebola, Maria Monsalud Martin-Aurioles, Esther Fernández Prior, África Gonzalez-Correa, Jose Antonio |
Departamento | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología |
Fecha de publicación | 2023-01-11 |
Fecha de depósito | 2023-06-22 |
Publicado en |
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Resumen | The aim of this study was to analyze the possible nephroprotective effect of 3’,4’-dihydroxy
phenylglycol (DHPG), a polyphenolic compound of extra virgin olive oil (EVOO), on renal lesions
in an experimental model of ... The aim of this study was to analyze the possible nephroprotective effect of 3’,4’-dihydroxy phenylglycol (DHPG), a polyphenolic compound of extra virgin olive oil (EVOO), on renal lesions in an experimental model of type 1 diabetes. Rats were distributed as follows: healthy normoglycemic rats (NDR), diabetic rats treated with saline (DR), and DR treated with 0.5 mg/kg/day or 1 mg/kg/day of DHPG. DR showed a significantly higher serum and renal oxidative and nitrosative stress profile than NDR, as well as reduced prostacyclin production and renal damage (defined as urinary protein excretion, reduced creatinine clearance, increased glomerular volume, and increased glomerulosclerosis index). DHPG reduced the oxidative and nitrosative stress and increased prostacyclin production (a 59.2% reduction in DR and 34.7–7.8% reduction in DHPG-treated rats), as well as 38–56% reduction in urinary protein excretion and 22–46% reduction in glomerular morphological parameters (after the treatment with 0.5 or 1 mg/kg/day, respectively). Conclusions: DHPG administration to type 1-like diabetic rats exerts a nephroprotective effect probably due to the sum of its antioxidant (Pearson’s coefficient 0.68–0.74), antinitrosative (Pearson’s coefficient 0.83), and prostacyclin production regulator (Pearson’s coefficient 0.75) effects. |
Agencias financiadoras | Consejería de Salud. Junta de Andalucía. España |
Identificador del proyecto | PI-0129-2017 |
Cita | Rodriguez-Perez, M.D., Santiago-Corral, L., Ortega-Hombrados, L., Verdugo, C., Arrebola, M.M., Martin-Aurioles, E.,...,Gonzalez-Correa, J.A. (2023). The Effect of the Extra Virgin Olive Oil Minor Phenolic Compound 3',4'-Dihydroxyphenylglycol in Experimental Diabetic Kidney Disease. NUTRIENTS, 15 (2), 377. https://doi.org/10.3390/nu15020377. |
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