dc.creator | Rodriguez-Perez, Maria Dolores | es |
dc.creator | Santiago-Corral, Laura | es |
dc.creator | Ortega-Hombrados, Laura | es |
dc.creator | Verdugo, Cristina | es |
dc.creator | Arrebola, Maria Monsalud | es |
dc.creator | Martin-Aurioles, Esther | es |
dc.creator | Fernández Prior, África | es |
dc.creator | Gonzalez-Correa, Jose Antonio | es |
dc.date.accessioned | 2023-06-22T13:48:12Z | |
dc.date.available | 2023-06-22T13:48:12Z | |
dc.date.issued | 2023-01-11 | |
dc.identifier.citation | Rodriguez-Perez, M.D., Santiago-Corral, L., Ortega-Hombrados, L., Verdugo, C., Arrebola, M.M., Martin-Aurioles, E.,...,Gonzalez-Correa, J.A. (2023). The Effect of the Extra Virgin Olive Oil Minor Phenolic Compound 3',4'-Dihydroxyphenylglycol in Experimental Diabetic Kidney Disease. NUTRIENTS, 15 (2), 377. https://doi.org/10.3390/nu15020377. | |
dc.identifier.issn | 2072-6643 | es |
dc.identifier.uri | https://hdl.handle.net/11441/147423 | |
dc.description.abstract | The aim of this study was to analyze the possible nephroprotective effect of 3’,4’-dihydroxy
phenylglycol (DHPG), a polyphenolic compound of extra virgin olive oil (EVOO), on renal lesions
in an experimental model of type 1 diabetes. Rats were distributed as follows: healthy normoglycemic rats (NDR), diabetic rats treated with saline (DR), and DR treated with 0.5 mg/kg/day
or 1 mg/kg/day of DHPG. DR showed a significantly higher serum and renal oxidative and nitrosative stress profile than NDR, as well as reduced prostacyclin production and renal damage
(defined as urinary protein excretion, reduced creatinine clearance, increased glomerular volume,
and increased glomerulosclerosis index). DHPG reduced the oxidative and nitrosative stress and
increased prostacyclin production (a 59.2% reduction in DR and 34.7–7.8% reduction in DHPG-treated
rats), as well as 38–56% reduction in urinary protein excretion and 22–46% reduction in glomerular
morphological parameters (after the treatment with 0.5 or 1 mg/kg/day, respectively). Conclusions:
DHPG administration to type 1-like diabetic rats exerts a nephroprotective effect probably due to the
sum of its antioxidant (Pearson’s coefficient 0.68–0.74), antinitrosative (Pearson’s coefficient 0.83),
and prostacyclin production regulator (Pearson’s coefficient 0.75) effects. | es |
dc.format | application/pdf | es |
dc.format.extent | 11 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | NUTRIENTS, 15 (2), 377. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | 3 0 ,40 -dihydroxyphenylglycol | es |
dc.subject | Diabetes mellitus | es |
dc.subject | Nephropathy | es |
dc.subject | Oxidative stress | es |
dc.title | The Effect of the Extra Virgin Olive Oil Minor Phenolic Compound 3',4'-Dihydroxyphenylglycol in Experimental Diabetic Kidney Disease | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.relation.projectID | PI-0129-2017 | es |
dc.relation.publisherversion | https://www.mdpi.com/2072-6643/15/2/377 | es |
dc.identifier.doi | 10.3390/nu15020377 | es |
dc.journaltitle | NUTRIENTS | es |
dc.publication.volumen | 15 | es |
dc.publication.issue | 2 | es |
dc.publication.initialPage | 377 | es |
dc.contributor.funder | Consejería de Salud. Junta de Andalucía. España | es |