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dc.creatorDelezie, Julienes
dc.creatorWeihrauch, Martines
dc.creatorMaier, Geraldinees
dc.creatorTejero, Rocíoes
dc.creatorHam, Daniel J.es
dc.creatorGill, Jonathan F.es
dc.creatorTabares, Lucíaes
dc.creatorHandschin, Christophes
dc.date.accessioned2023-05-23T12:53:23Z
dc.date.available2023-05-23T12:53:23Z
dc.date.issued2019-07-18
dc.identifier.citationDelezie, J., Weihrauch, M., Maier, G., Tejero, R., Ham, D.J., Gill, J.F.,...,Handschin, C. (2019). BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116 (32), 16111-16120. https://doi.org/10.1073/pnas.1900544116.
dc.identifier.issn0027-8424es
dc.identifier.urihttps://hdl.handle.net/11441/146544
dc.description.abstractBrain-derived neurotrophic factor (BDNF) influences the differentiation, plasticity, and survival of central neurons and likewise, affects the development of the neuromuscular system. Besides its neuronal origin, BDNF is also a member of the myokine family. However, the role of skeletal muscle-derived BDNF in regulating neuromuscular physiology in vivo remains unclear. Using gainand loss-of-function animal models, we show that muscle-specific ablation of BDNF shifts the proportion of muscle fibers from type IIB to IIX, concomitant with elevated slow muscle-type gene expression. Furthermore, BDNF deletion reduces motor end plate volume without affecting neuromuscular junction (NMJ) integrity. These morphological changes are associated with slow muscle function and a greater resistance to contraction-induced fatigue. Conversely, BDNF overexpression promotes a fast muscle-type gene program and elevates glycolytic fiber number. These findings indicate that BDNF is required for fiber-type specification and provide insights into its potential modulation as a therapeutic target in muscle diseases.es
dc.formatapplication/pdfes
dc.format.extent10 p.es
dc.language.isoenges
dc.publisherNATL ACAD SCIENCESes
dc.relation.ispartofPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116 (32), 16111-16120.
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Estados Unidos de América*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectNeurotrophic factores
dc.subjectMyokinees
dc.subjectOxidative fiberes
dc.subjectNeuromuscular junctiones
dc.subjectEndurance exercisees
dc.titleBDNF is a mediator of glycolytic fiber-type specification in mouse skeletal musclees
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Fisiología Médica y Biofísicaes
dc.relation.publisherversionhttps://www.pnas.org/doi/full/10.1073/pnas.1900544116es
dc.identifier.doi10.1073/pnas.1900544116es
dc.journaltitlePROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAes
dc.publication.volumen116es
dc.publication.issue32es
dc.publication.initialPage16111es
dc.publication.endPage16120es

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