dc.creator | Delezie, Julien | es |
dc.creator | Weihrauch, Martin | es |
dc.creator | Maier, Geraldine | es |
dc.creator | Tejero, Rocío | es |
dc.creator | Ham, Daniel J. | es |
dc.creator | Gill, Jonathan F. | es |
dc.creator | Tabares, Lucía | es |
dc.creator | Handschin, Christoph | es |
dc.date.accessioned | 2023-05-23T12:53:23Z | |
dc.date.available | 2023-05-23T12:53:23Z | |
dc.date.issued | 2019-07-18 | |
dc.identifier.citation | Delezie, J., Weihrauch, M., Maier, G., Tejero, R., Ham, D.J., Gill, J.F.,...,Handschin, C. (2019). BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116 (32), 16111-16120. https://doi.org/10.1073/pnas.1900544116. | |
dc.identifier.issn | 0027-8424 | es |
dc.identifier.uri | https://hdl.handle.net/11441/146544 | |
dc.description.abstract | Brain-derived neurotrophic factor (BDNF) influences the differentiation, plasticity, and survival of central neurons and likewise,
affects the development of the neuromuscular system. Besides its
neuronal origin, BDNF is also a member of the myokine family.
However, the role of skeletal muscle-derived BDNF in regulating
neuromuscular physiology in vivo remains unclear. Using gainand loss-of-function animal models, we show that muscle-specific
ablation of BDNF shifts the proportion of muscle fibers from type
IIB to IIX, concomitant with elevated slow muscle-type gene
expression. Furthermore, BDNF deletion reduces motor end plate
volume without affecting neuromuscular junction (NMJ) integrity.
These morphological changes are associated with slow muscle
function and a greater resistance to contraction-induced fatigue.
Conversely, BDNF overexpression promotes a fast muscle-type
gene program and elevates glycolytic fiber number. These findings
indicate that BDNF is required for fiber-type specification and
provide insights into its potential modulation as a therapeutic
target in muscle diseases. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 p. | es |
dc.language.iso | eng | es |
dc.publisher | NATL ACAD SCIENCES | es |
dc.relation.ispartof | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116 (32), 16111-16120. | |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Estados Unidos de América | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | Neurotrophic factor | es |
dc.subject | Myokine | es |
dc.subject | Oxidative fiber | es |
dc.subject | Neuromuscular junction | es |
dc.subject | Endurance exercise | es |
dc.title | BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.relation.publisherversion | https://www.pnas.org/doi/full/10.1073/pnas.1900544116 | es |
dc.identifier.doi | 10.1073/pnas.1900544116 | es |
dc.journaltitle | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | es |
dc.publication.volumen | 116 | es |
dc.publication.issue | 32 | es |
dc.publication.initialPage | 16111 | es |
dc.publication.endPage | 16120 | es |