dc.creator | Fernández-Chacón, Rafael | es |
dc.creator | Wolfel, M. | es |
dc.creator | Nishimune, H. | es |
dc.creator | Tabares, Lucía | es |
dc.creator | Schmitz, Frank | es |
dc.creator | Castellano-Munoz, M. | es |
dc.creator | Rosenmund, Christian | es |
dc.creator | Montesinos Gutiérrez, María Luz | es |
dc.creator | Sudhof, TC | es |
dc.date.accessioned | 2023-05-22T13:25:33Z | |
dc.date.available | 2023-05-22T13:25:33Z | |
dc.date.issued | 2004-04-22 | |
dc.identifier.citation | Fernández-Chacón, R., Wolfel, M., Nishimune, H., Tabares, L., Schmitz, F., Castellano-Munoz, M.,...,Sudhof, T. (2004). The synaptic vesicle protein CSP alpha prevents presynaptic degeneration. NEURON, 42 (2), 237-251. https://doi.org/10.1016/S0896-6273(04)00190-4. | |
dc.identifier.issn | 0896-6273 | es |
dc.identifier.uri | https://hdl.handle.net/11441/146495 | |
dc.description.abstract | Cysteine string protein α (CSPα)—an abundant synaptic vesicle protein that contains a DNA-J domain characteristic of Hsp40 chaperones—is thought to regulate Ca2+ channels and/or synaptic vesicle exocytosis. We now show that, in young mice, deletion of CSPα does not impair survival and causes no significant changes in presynaptic Ca2+ currents or synaptic vesicle exocytosis as measured in the Calyx of Held synapse. At 2–4 weeks of age, however, CSPα-deficient mice develop a progressive, fatal sensorimotor disorder. The neuromuscular junctions and Calyx synapses of CSPα-deficient mice exhibit increasing neurodegenerative changes, synaptic transmission becomes severely impaired, and the mutant mice die at ∼2 months of age. Our data suggest that CSPα is not essential for the normal operation of Ca2+ channels or exocytosis but acts as a presynaptic chaperone that maintains continued synaptic function, raising the possibility that enhanced CSPα function could attenuate neurodegenerative diseases. | es |
dc.format | application/pdf | es |
dc.format.extent | 15 p. | es |
dc.language.iso | eng | es |
dc.publisher | CELL PRESS | es |
dc.relation.ispartof | NEURON, 42 (2), 237-251. | |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Estados Unidos de América | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.title | The synaptic vesicle protein CSP alpha prevents presynaptic degeneration | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0896627304001904?via%3Dihub | es |
dc.identifier.doi | 10.1016/S0896-6273(04)00190-4 | es |
dc.journaltitle | NEURON | es |
dc.publication.volumen | 42 | es |
dc.publication.issue | 2 | es |
dc.publication.initialPage | 237 | es |
dc.publication.endPage | 251 | es |